Résumé
Increased life expectancy due to medical advances has greatly expanded the number of elderly people. This increase in the number of elderly people is a challenge to the whole world as aging is the predominant risk factor for almost all major neurodegenerative diseases, and neurodegenerative diseases pose an enormous social, emotional and economic burden.Cellular senescence is one of the hallmarks of aging and is described as a physiological mechanism whereby a proliferating cell undergoes a stable cell cycle arrest upon damage or stress. Several studies support the involvement of cellular senescence in Alzheimer's disease (AD), leading to the targeting of senescent cells for the treatment of this disease.
While less well understood mechanistically, some studies have shown that, in vivo ,senescent cell accumulation contribute to age-related diseases and senolytics can be used as a therapy for the treatment of AD.
Specifically, this bibliographic research seeks to describe the link between cellular senescence and Alzheimer’s disease, and how the exploitation of strategies to eliminate senescent cells with senolytics may contribute to delay Alzheimer’s disease.
| la date de réponse | 25 août 2023 |
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| langue originale | Anglais |
| L'institution diplômante |
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| Superviseur | Florence Debacq-Chainiaux (Promoteur) |