Résumé
[en] Attenuation of p53 activity appears to be a major step in Human T-lymphotropic virus type 1 (HTLV-1) Tax transformation. However, p53 genomic mutations are late and rather infrequent events in HTLV-1 induced Adult T cell leukemia (ATL). The paper by Zane et al. shows that a mediator of p53 activity, Wild-type p53-induced phosphatase 1 (Wip1), contributes to Tax-induced oncogenesis in a mouse model. Wip1 may therefore be a novel target for therapeutic approaches.
langue originale | Anglais |
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Pages (de - à) | 115 |
Nombre de pages | 1 |
journal | Retrovirology |
Volume | 9 |
Numéro de publication | 1 |
Les DOIs | |
Etat de la publication | Publié - 2012 |
Modification externe | Oui |