Vaccination against delta-Retroviruses: The Bovine Leukemia Virus Paradigm.

G. Gutierrez; S. M. Rodriguez; Alix de Brogniez; N. Gillet; R. Golime; Arsène Burny; J.-P. Jaworski; I. Alvarez; L. Vagnoni; K. Trono; L. Willems

Vaccination against delta-Retroviruses: The Bovine Leukemia Virus Paradigm.

G. Gutierrez, S. M. Rodriguez, Alix de Brogniez, N. Gillet, R. Golime, Arsène Burny, J.-P. Jaworski, I. Alvarez, L. Vagnoni, K. Trono, L. Willems

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Résumé

[en] Bovine leukemia virus (BLV) and human T-lymphotropic virus type 1 (HTLV-1) are closely related d-retroviruses that induce hematological diseases. HTLV-1 infects about 15 million people worldwide, mainly in subtropical areas. HTLV-1 induces a wide spectrum of diseases (e.g., HTLV-associated myelopathy/tropical spastic paraparesis) and leukemia/lymphoma (adult T-cell leukemia). Bovine leukemia virus is a major pathogen of cattle, causing important economic losses due to a reduction in production, export limitations and lymphoma-associated death. In the absence of satisfactory treatment for these diseases and besides the prevention of transmission, the best option to reduce the prevalence of d-retroviruses is vaccination. Here, we provide an overview of the different vaccination strategies in the BLV model and outline key parameters required for vaccine efficacy.

langue originale	Anglais
Pages (de - à)	2416-2427
Nombre de pages	12
journal	Viruses
Volume	6
Numéro de publication	6
Etat de la publication	Publié - 2014
Modification externe	Oui

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@article{f97b6eadc68a465c9d6d786458c5babe,

title = "Vaccination against delta-Retroviruses: The Bovine Leukemia Virus Paradigm.",

abstract = "[en] Bovine leukemia virus (BLV) and human T-lymphotropic virus type 1 (HTLV-1) are closely related d-retroviruses that induce hematological diseases. HTLV-1 infects about 15 million people worldwide, mainly in subtropical areas. HTLV-1 induces a wide spectrum of diseases (e.g., HTLV-associated myelopathy/tropical spastic paraparesis) and leukemia/lymphoma (adult T-cell leukemia). Bovine leukemia virus is a major pathogen of cattle, causing important economic losses due to a reduction in production, export limitations and lymphoma-associated death. In the absence of satisfactory treatment for these diseases and besides the prevention of transmission, the best option to reduce the prevalence of d-retroviruses is vaccination. Here, we provide an overview of the different vaccination strategies in the BLV model and outline key parameters required for vaccine efficacy.",

keywords = "Sciences de la sant{\'e} humaine => Immunologie maladie infectieuse",

author = "G. Gutierrez and Rodriguez, {S. M.} and Brogniez, {Alix de} and N. Gillet and R. Golime and Ars{\`e}ne Burny and J.-P. Jaworski and I. Alvarez and L. Vagnoni and K. Trono and L. Willems",

year = "2014",

language = "English",

volume = "6",

pages = "2416--2427",

journal = "Viruses",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "6",

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TY - JOUR

T1 - Vaccination against delta-Retroviruses: The Bovine Leukemia Virus Paradigm.

AU - Gutierrez, G.

AU - Rodriguez, S. M.

AU - Brogniez, Alix de

AU - Gillet, N.

AU - Golime, R.

AU - Burny, Arsène

AU - Jaworski, J.-P.

AU - Alvarez, I.

AU - Vagnoni, L.

AU - Trono, K.

AU - Willems, L.

PY - 2014

Y1 - 2014

N2 - [en] Bovine leukemia virus (BLV) and human T-lymphotropic virus type 1 (HTLV-1) are closely related d-retroviruses that induce hematological diseases. HTLV-1 infects about 15 million people worldwide, mainly in subtropical areas. HTLV-1 induces a wide spectrum of diseases (e.g., HTLV-associated myelopathy/tropical spastic paraparesis) and leukemia/lymphoma (adult T-cell leukemia). Bovine leukemia virus is a major pathogen of cattle, causing important economic losses due to a reduction in production, export limitations and lymphoma-associated death. In the absence of satisfactory treatment for these diseases and besides the prevention of transmission, the best option to reduce the prevalence of d-retroviruses is vaccination. Here, we provide an overview of the different vaccination strategies in the BLV model and outline key parameters required for vaccine efficacy.

AB - [en] Bovine leukemia virus (BLV) and human T-lymphotropic virus type 1 (HTLV-1) are closely related d-retroviruses that induce hematological diseases. HTLV-1 infects about 15 million people worldwide, mainly in subtropical areas. HTLV-1 induces a wide spectrum of diseases (e.g., HTLV-associated myelopathy/tropical spastic paraparesis) and leukemia/lymphoma (adult T-cell leukemia). Bovine leukemia virus is a major pathogen of cattle, causing important economic losses due to a reduction in production, export limitations and lymphoma-associated death. In the absence of satisfactory treatment for these diseases and besides the prevention of transmission, the best option to reduce the prevalence of d-retroviruses is vaccination. Here, we provide an overview of the different vaccination strategies in the BLV model and outline key parameters required for vaccine efficacy.

KW - Sciences de la santé humaine => Immunologie maladie infectieuse

M3 - Article

VL - 6

SP - 2416

EP - 2427

JO - Viruses

JF - Viruses

IS - 6

ER -

Vaccination against delta-Retroviruses: The Bovine Leukemia Virus Paradigm.

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