UV, stress and aging

Florence Debacq-Chainiaux; Cedric Leduc; Alix Verbeke; Olivier Toussaint

doi:10.4161/derm.23652

UV, stress and aging

Florence Debacq-Chainiaux
, Cedric Leduc
, Alix Verbeke
, Olivier Toussaint

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Résumé

Skin is a model of choice in studies on aging. Indeed, skin aging can be modulated by internal and external factors, reflecting its complexity. Two types of skin aging have been identified: intrinsic, mainly genetically determined and extrinsic-also called "photo-aging"-resulting on the impact of environmental stress and more precisely of UV rays. Simplified in vitro models, based on cellular senescence, have been developed to study the relationship between UV and aging. These models vary on the cell type (fibroblasts or keratinocytes, normal or immortalized) and the type of UV used (UVA or UVB).

langue originale	Anglais
Pages (de - à)	236-40
Nombre de pages	5
journal	Dermato-endocrinology
Volume	4
Numéro de publication	3
Les DOIs	https://doi.org/10.4161/derm.23652
Etat de la publication	Publié - 1 juil. 2012

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10.4161/derm.23652

2012-16 Debacq-Chainiaux DermatoendocrinolVersion finale publiée, 353 KB

Contient cette citation

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title = "UV, stress and aging",

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author = "Florence Debacq-Chainiaux and Cedric Leduc and Alix Verbeke and Olivier Toussaint",

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AU - Debacq-Chainiaux, Florence

AU - Leduc, Cedric

AU - Verbeke, Alix

AU - Toussaint, Olivier

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N2 - Skin is a model of choice in studies on aging. Indeed, skin aging can be modulated by internal and external factors, reflecting its complexity. Two types of skin aging have been identified: intrinsic, mainly genetically determined and extrinsic-also called "photo-aging"-resulting on the impact of environmental stress and more precisely of UV rays. Simplified in vitro models, based on cellular senescence, have been developed to study the relationship between UV and aging. These models vary on the cell type (fibroblasts or keratinocytes, normal or immortalized) and the type of UV used (UVA or UVB).

AB - Skin is a model of choice in studies on aging. Indeed, skin aging can be modulated by internal and external factors, reflecting its complexity. Two types of skin aging have been identified: intrinsic, mainly genetically determined and extrinsic-also called "photo-aging"-resulting on the impact of environmental stress and more precisely of UV rays. Simplified in vitro models, based on cellular senescence, have been developed to study the relationship between UV and aging. These models vary on the cell type (fibroblasts or keratinocytes, normal or immortalized) and the type of UV used (UVA or UVB).

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DO - 10.4161/derm.23652

M3 - Article

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ER -

UV, stress and aging

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