UV, stress and aging

Florence Debacq-Chainiaux, Cedric Leduc, Alix Verbeke, Olivier Toussaint

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Résumé

Skin is a model of choice in studies on aging. Indeed, skin aging can be modulated by internal and external factors, reflecting its complexity. Two types of skin aging have been identified: intrinsic, mainly genetically determined and extrinsic-also called "photo-aging"-resulting on the impact of environmental stress and more precisely of UV rays. Simplified in vitro models, based on cellular senescence, have been developed to study the relationship between UV and aging. These models vary on the cell type (fibroblasts or keratinocytes, normal or immortalized) and the type of UV used (UVA or UVB).
langue originaleAnglais
Pages (de - à)236-40
Nombre de pages5
journalDermato-endocrinology
Volume4
Numéro de publication3
Les DOIs
Etat de la publicationPublié - 1 juil. 2012

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