Using the nature of the achiral solvent to orient chiral resolution

Joséphine de Meester; Oleksii Shemchuk; Laurent Collard; Johan Wouters; Simon Baillieux; Koen Robeyns; Tom Leyssens

doi:10.1039/d4ce00124a

Using the nature of the achiral solvent to orient chiral resolution

Joséphine de Meester, Oleksii Shemchuk, Laurent Collard, Johan Wouters, Simon Baillieux, Koen Robeyns, Tom Leyssens

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

Résumé

We demonstrate the unprecedented phenomenon of solvent-oriented resolution of 1,1′-bi-2-naphtol (Binol). Using a resolution agent of a fixed handedness (R,R)-N,N′-dimethyl-1,2-diphenylethane-1,2-diamine (DADPE), we are able to resolve either the (S)- or (R)-enantiomer of Binol by a mere change of the achiral solvent.

langue originale	Anglais
Pages (de - à)	2056-2059
Nombre de pages	4
journal	CrystEngComm
Volume	26
Numéro de publication	15
Les DOIs	https://doi.org/10.1039/d4ce00124a
Etat de la publication	Publié - 15 mars 2024

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10.1039/d4ce00124a

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AU - de Meester, Joséphine

AU - Shemchuk, Oleksii

AU - Collard, Laurent

AU - Wouters, Johan

AU - Baillieux, Simon

AU - Robeyns, Koen

AU - Leyssens, Tom

PY - 2024/3/15

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AB - We demonstrate the unprecedented phenomenon of solvent-oriented resolution of 1,1′-bi-2-naphtol (Binol). Using a resolution agent of a fixed handedness (R,R)-N,N′-dimethyl-1,2-diphenylethane-1,2-diamine (DADPE), we are able to resolve either the (S)- or (R)-enantiomer of Binol by a mere change of the achiral solvent.

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Using the nature of the achiral solvent to orient chiral resolution

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