Upregulation of annexin A2 in H2O2-induced premature senescence as evidenced by 2D-DIGE proteome analysis

Aline Chrétien, Edouard Delaive, Marc Dieu, Catherine Demazy, Noëlle Ninane, Martine Raes, Olivier Toussaint

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

Résumé

Human diploid fibroblasts undergo premature senescence after treatment with sublethal concentration of H2O2. We report the first proteomic study of microsomal proteins in the context of H2O2-induced premature senescence by using 2D-DIGE approach. Twelve different proteins with altered abundance at day 3 after treatment with H2O2 were identified. Among them, we demonstrated a re-localization of annexin A2 in plasma membrane. © 2008 Elsevier Inc. All rights reserved.

langue originaleAnglais
Pages (de - à)353-359
Nombre de pages7
journalExperimental Gerontology
Volume43
Numéro de publication4
Les DOIs
Etat de la publicationPublié - avr. 2008

Empreinte digitale

Examiner les sujets de recherche de « Upregulation of annexin A2 in H<sub>2</sub>O<sub>2</sub>-induced premature senescence as evidenced by 2D-DIGE proteome analysis ». Ensemble, ils forment une empreinte digitale unique.

Contient cette citation