Upregulation of annexin A2 in H2O2-induced premature senescence as evidenced by 2D-DIGE proteome analysis

Aline Chrétien; Edouard Delaive; Marc Dieu; Catherine Demazy; Noëlle Ninane; Martine Raes; Olivier Toussaint

doi:10.1016/j.exger.2008.01.003

Upregulation of annexin A2 in H₂O₂-induced premature senescence as evidenced by 2D-DIGE proteome analysis

Aline Chrétien, Edouard Delaive, Marc Dieu, Catherine Demazy, Noëlle Ninane, Martine Raes, Olivier Toussaint

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

Résumé

Human diploid fibroblasts undergo premature senescence after treatment with sublethal concentration of H₂O₂. We report the first proteomic study of microsomal proteins in the context of H₂O₂-induced premature senescence by using 2D-DIGE approach. Twelve different proteins with altered abundance at day 3 after treatment with H₂O₂ were identified. Among them, we demonstrated a re-localization of annexin A2 in plasma membrane. © 2008 Elsevier Inc. All rights reserved.

langue originale	Anglais
Pages (de - à)	353-359
Nombre de pages	7
journal	Experimental Gerontology
Volume	43
Numéro de publication	4
Les DOIs	https://doi.org/10.1016/j.exger.2008.01.003
Etat de la publication	Publié - avr. 2008

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10.1016/j.exger.2008.01.003

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Contient cette citation

@article{2ed4d4108b9345729bead0d640e6488f,

title = "Upregulation of annexin A2 in H2O2-induced premature senescence as evidenced by 2D-DIGE proteome analysis",

abstract = "Human diploid fibroblasts undergo premature senescence after treatment with sublethal concentration of H2O2. We report the first proteomic study of microsomal proteins in the context of H2O2-induced premature senescence by using 2D-DIGE approach. Twelve different proteins with altered abundance at day 3 after treatment with H2O2 were identified. Among them, we demonstrated a re-localization of annexin A2 in plasma membrane. {\textcopyright} 2008 Elsevier Inc. All rights reserved.",

keywords = "Annexin, Fibroblasts, HO, Membrane, Proteomics, Senescence",

author = "Aline Chr{\'e}tien and Edouard Delaive and Marc Dieu and Catherine Demazy and No{\"e}lle Ninane and Martine Raes and Olivier Toussaint",

note = "Publication code : RES. ACAD.",

year = "2008",

month = apr,

doi = "10.1016/j.exger.2008.01.003",

language = "English",

volume = "43",

pages = "353--359",

journal = "Experimental Gerontology",

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TY - JOUR

T1 - Upregulation of annexin A2 in H2O2-induced premature senescence as evidenced by 2D-DIGE proteome analysis

AU - Chrétien, Aline

AU - Delaive, Edouard

AU - Dieu, Marc

AU - Demazy, Catherine

AU - Ninane, Noëlle

AU - Raes, Martine

AU - Toussaint, Olivier

N1 - Publication code : RES. ACAD.

PY - 2008/4

Y1 - 2008/4

N2 - Human diploid fibroblasts undergo premature senescence after treatment with sublethal concentration of H2O2. We report the first proteomic study of microsomal proteins in the context of H2O2-induced premature senescence by using 2D-DIGE approach. Twelve different proteins with altered abundance at day 3 after treatment with H2O2 were identified. Among them, we demonstrated a re-localization of annexin A2 in plasma membrane. © 2008 Elsevier Inc. All rights reserved.

AB - Human diploid fibroblasts undergo premature senescence after treatment with sublethal concentration of H2O2. We report the first proteomic study of microsomal proteins in the context of H2O2-induced premature senescence by using 2D-DIGE approach. Twelve different proteins with altered abundance at day 3 after treatment with H2O2 were identified. Among them, we demonstrated a re-localization of annexin A2 in plasma membrane. © 2008 Elsevier Inc. All rights reserved.

KW - Annexin

KW - Fibroblasts

KW - HO

KW - Membrane

KW - Proteomics

KW - Senescence

UR - http://www.scopus.com/inward/record.url?scp=40649095622&partnerID=8YFLogxK

U2 - 10.1016/j.exger.2008.01.003

DO - 10.1016/j.exger.2008.01.003

M3 - Article

C2 - 18289818

VL - 43

SP - 353

EP - 359

JO - Experimental Gerontology

JF - Experimental Gerontology

IS - 4

ER -

Upregulation of annexin A2 in H2O2-induced premature senescence as evidenced by 2D-DIGE proteome analysis

Résumé

Accès au document

Autres fichiers et liens

Empreinte digitale

Équipement

Spectrométrie de masse (MASUN)

Contient cette citation

Upregulation of annexin A2 in H₂O₂-induced premature senescence as evidenced by 2D-DIGE proteome analysis