Unraveling biochemical pathways affected by mitochondrial dysfunctions using metabolomic approaches

Résultats de recherche: Contribution à un journal/une revueArticle

Résumé

Mitochondrial dysfunction(s) (MDs) can be defined as alterations in the mitochondria, including mitochondrial uncoupling, mitochondrial depolarization, inhibition of the mitochondrial respiratory chain, mitochondrial network fragmentation, mitochondrial or nuclear DNA mutations and the mitochondrial accumulation of protein aggregates. All these MDs are known to alter the capacity of ATP production and are observed in several pathological states/diseases, including cancer, obesity, muscle and neurological disorders. The induction of MDs can also alter the secretion of several metabolites, reactive oxygen species production and modify several cell-signalling pathways to resolve the mitochondrial dysfunction or ultimately trigger cell death. Many metabolites, such as fatty acids and derived compounds, could be secreted into the blood stream by cells suffering from mitochondrial alterations. In this review, we summarize how a mitochondrial uncoupling can modify metabolites, the signalling pathways and transcription factors involved in this process. We describe how to identify the causes or consequences of mitochondrial dysfunction using metabolomics (liquid and gas chromatography associated with mass spectrometry analysis, NMR spectroscopy) in the obesity and insulin resistance thematic.
langueAnglais
Pages831-878
Nombre de pages47
journalMetabolites
Volume4
Numéro3
Date de mise en ligne précoce25 sept. 2014
Les DOIs
étatPublié - 25 sept. 2014

Empreinte digitale

Metabolomics
Metabolites
Muscle Neoplasms
Obesity
Mitochondrial Proteins
Muscular Diseases
Electron Transport
Nervous System Diseases
Gas Chromatography
Cell signaling
Insulin Resistance
Reactive Oxygen Species
Blood Cells
Mass Spectrometry
Mitochondria
Cell Death
Transcription Factors
Magnetic Resonance Spectroscopy
Fatty Acids
Adenosine Triphosphate

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    Citer ceci

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    title = "Unraveling biochemical pathways affected by mitochondrial dysfunctions using metabolomic approaches",
    abstract = "Mitochondrial dysfunction(s) (MDs) can be defined as alterations in the mitochondria, including mitochondrial uncoupling, mitochondrial depolarization, inhibition of the mitochondrial respiratory chain, mitochondrial network fragmentation, mitochondrial or nuclear DNA mutations and the mitochondrial accumulation of protein aggregates. All these MDs are known to alter the capacity of ATP production and are observed in several pathological states/diseases, including cancer, obesity, muscle and neurological disorders. The induction of MDs can also alter the secretion of several metabolites, reactive oxygen species production and modify several cell-signalling pathways to resolve the mitochondrial dysfunction or ultimately trigger cell death. Many metabolites, such as fatty acids and derived compounds, could be secreted into the blood stream by cells suffering from mitochondrial alterations. In this review, we summarize how a mitochondrial uncoupling can modify metabolites, the signalling pathways and transcription factors involved in this process. We describe how to identify the causes or consequences of mitochondrial dysfunction using metabolomics (liquid and gas chromatography associated with mass spectrometry analysis, NMR spectroscopy) in the obesity and insulin resistance thematic.",
    keywords = "Metabolites, Mitochondria Uncoupling, Mass Spectrometry, NMR, obesity",
    author = "St{\'e}phane Demine and Nagabushana Reddy and Patricia Renard and Martine Raes and Thierry Arnould",
    year = "2014",
    month = "9",
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    doi = "10.3390/metabo4030831",
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    T1 - Unraveling biochemical pathways affected by mitochondrial dysfunctions using metabolomic approaches

    AU - Demine,Stéphane

    AU - Reddy,Nagabushana

    AU - Renard,Patricia

    AU - Raes,Martine

    AU - Arnould,Thierry

    PY - 2014/9/25

    Y1 - 2014/9/25

    N2 - Mitochondrial dysfunction(s) (MDs) can be defined as alterations in the mitochondria, including mitochondrial uncoupling, mitochondrial depolarization, inhibition of the mitochondrial respiratory chain, mitochondrial network fragmentation, mitochondrial or nuclear DNA mutations and the mitochondrial accumulation of protein aggregates. All these MDs are known to alter the capacity of ATP production and are observed in several pathological states/diseases, including cancer, obesity, muscle and neurological disorders. The induction of MDs can also alter the secretion of several metabolites, reactive oxygen species production and modify several cell-signalling pathways to resolve the mitochondrial dysfunction or ultimately trigger cell death. Many metabolites, such as fatty acids and derived compounds, could be secreted into the blood stream by cells suffering from mitochondrial alterations. In this review, we summarize how a mitochondrial uncoupling can modify metabolites, the signalling pathways and transcription factors involved in this process. We describe how to identify the causes or consequences of mitochondrial dysfunction using metabolomics (liquid and gas chromatography associated with mass spectrometry analysis, NMR spectroscopy) in the obesity and insulin resistance thematic.

    AB - Mitochondrial dysfunction(s) (MDs) can be defined as alterations in the mitochondria, including mitochondrial uncoupling, mitochondrial depolarization, inhibition of the mitochondrial respiratory chain, mitochondrial network fragmentation, mitochondrial or nuclear DNA mutations and the mitochondrial accumulation of protein aggregates. All these MDs are known to alter the capacity of ATP production and are observed in several pathological states/diseases, including cancer, obesity, muscle and neurological disorders. The induction of MDs can also alter the secretion of several metabolites, reactive oxygen species production and modify several cell-signalling pathways to resolve the mitochondrial dysfunction or ultimately trigger cell death. Many metabolites, such as fatty acids and derived compounds, could be secreted into the blood stream by cells suffering from mitochondrial alterations. In this review, we summarize how a mitochondrial uncoupling can modify metabolites, the signalling pathways and transcription factors involved in this process. We describe how to identify the causes or consequences of mitochondrial dysfunction using metabolomics (liquid and gas chromatography associated with mass spectrometry analysis, NMR spectroscopy) in the obesity and insulin resistance thematic.

    KW - Metabolites, Mitochondria Uncoupling, Mass Spectrometry, NMR, obesity

    U2 - 10.3390/metabo4030831

    DO - 10.3390/metabo4030831

    M3 - Article

    VL - 4

    SP - 831

    EP - 878

    JO - Metabolites

    T2 - Metabolites

    JF - Metabolites

    SN - 2218-1989

    IS - 3

    ER -