TY - JOUR
T1 - Uncovering the Relationship between Selenium Status, Age, Health, and Dietary Habits
T2 - Insights from a Large Population Study including Nonagenarian Offspring from the MARK-AGE Project
AU - Giacconi, Robertina
AU - Piacenza, Francesco
AU - Aversano, Valentina
AU - Zampieri, Michele
AU - Bürkle, Alexander
AU - Villanueva, María Moreno
AU - Dollé, Martijn E.T.
AU - Jansen, Eugène
AU - Grune, Tilman
AU - Gonos, Efstathios S.
AU - Franceschi, Claudio
AU - Capri, Miriam
AU - Weinberger, Birgit
AU - Sikora, Ewa
AU - Toussaint, Olivier
AU - Debacq-Chainiaux, Florence
AU - Stuetz, Wolfgang
AU - Slagboom, Pieternella Eline
AU - Bernhardt, Jürgen
AU - Fernández-Sánchez, Maria Luisa
AU - Provinciali, Mauro
AU - Malavolta, Marco
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/5
Y1 - 2023/5
N2 - An inadequate selenium (Se) status can accelerate the aging process, increasing the vulnerability to age-related diseases. The study aimed to investigate plasma Se and Se species in a large population, including 2200 older adults from the general population (RASIG), 514 nonagenarian offspring (GO), and 293 GO Spouses (SGO). Plasma Se levels in women exhibit an inverted U-shaped pattern, increasing with age until the post-menopausal period and then declining. Conversely, men exhibit a linear decline in plasma Se levels with age. Subjects from Finland had the highest plasma Se values, while those from Poland had the lowest ones. Plasma Se was influenced by fish and vitamin consumption, but there were no significant differences between RASIG, GO, and SGO. Plasma Se was positively associated with albumin, HDL, total cholesterol, fibrinogen, and triglycerides and negatively associated with homocysteine. Fractionation analysis showed that Se distribution among plasma selenoproteins is affected by age, glucometabolic and inflammatory factors, and being GO or SGO. These findings show that sex-specific, nutritional, and inflammatory factors play a crucial role in the regulation of Se plasma levels throughout the aging process and that the shared environment of GO and SGO plays a role in their distinctive Se fractionation.
AB - An inadequate selenium (Se) status can accelerate the aging process, increasing the vulnerability to age-related diseases. The study aimed to investigate plasma Se and Se species in a large population, including 2200 older adults from the general population (RASIG), 514 nonagenarian offspring (GO), and 293 GO Spouses (SGO). Plasma Se levels in women exhibit an inverted U-shaped pattern, increasing with age until the post-menopausal period and then declining. Conversely, men exhibit a linear decline in plasma Se levels with age. Subjects from Finland had the highest plasma Se values, while those from Poland had the lowest ones. Plasma Se was influenced by fish and vitamin consumption, but there were no significant differences between RASIG, GO, and SGO. Plasma Se was positively associated with albumin, HDL, total cholesterol, fibrinogen, and triglycerides and negatively associated with homocysteine. Fractionation analysis showed that Se distribution among plasma selenoproteins is affected by age, glucometabolic and inflammatory factors, and being GO or SGO. These findings show that sex-specific, nutritional, and inflammatory factors play a crucial role in the regulation of Se plasma levels throughout the aging process and that the shared environment of GO and SGO plays a role in their distinctive Se fractionation.
KW - aging
KW - inflammation
KW - longevity
KW - plasma selenium
KW - selenium fractionation
UR - http://www.scopus.com/inward/record.url?scp=85159053445&partnerID=8YFLogxK
U2 - 10.3390/nu15092182
DO - 10.3390/nu15092182
M3 - Article
AN - SCOPUS:85159053445
SN - 2072-6643
VL - 15
JO - Nutrients
JF - Nutrients
IS - 9
M1 - 2182
ER -