Unconventional endocytic mechanisms

Henri François Renard, Emmanuel Boucrot

Résultats de recherche: Contribution à un journal/une revueArticle de revueRevue par des pairs


Endocytosis mediates the uptake of extracellular proteins, micronutrients and transmembrane cell surface proteins. Importantly, many viruses, toxins and bacteria hijack endocytosis to infect cells. The canonical pathway is clathrin-mediated endocytosis (CME) and is active in all eukaryotic cells to support critical house-keeping functions. Unconventional mechanisms of endocytosis exit in parallel of CME, to internalize specific cargoes and support various cellular functions. These clathrin-independent endocytic (CIE) routes use three distinct mechanisms: acute signaling-induced membrane remodeling drives macropinocytosis, activity-dependent bulk endocytosis (ADBE), massive endocytosis (MEND) and EGFR non-clathrin endocytosis (EGFR-NCE). Cargo capture and local membrane deformation by cytosolic proteins is used by fast endophilin-mediated endocytosis (FEME), IL-2Rβ endocytosis and ultrafast endocytosis at synapses. Finally, the formation of endocytic pits by clustering of extracellular lipids or cargoes according to the Glycolipid-Lectin (GL-Lect) hypothesis mediates the uptake of SV40 virus, Shiga and cholera toxins, and galectin-clustered receptors by the CLIC/GEEC and the endophilin-A3-mediated CIE.

langue originaleAnglais
Pages (de - à)120-129
Nombre de pages10
journalCurrent Opinion in Cell Biology
Date de mise en ligne précoce13 avr. 2021
Les DOIs
Etat de la publicationE-pub ahead of print - 13 avr. 2021

Empreinte digitale

Examiner les sujets de recherche de « Unconventional endocytic mechanisms ». Ensemble, ils forment une empreinte digitale unique.

Contient cette citation