Tumor-infiltrating lymphocytes: Apparently good for melanoma patients. but why?

Arcadi Cipponi; Grégoire Wieërs; Nicolas Van Baren; Pierre G. Coulie

doi:10.1007/s00262-011-1026-2

Tumor-infiltrating lymphocytes: Apparently good for melanoma patients. but why?

Arcadi Cipponi
, Grégoire Wieërs
, Nicolas Van Baren
, Pierre G. Coulie

Résultats de recherche: Contribution à un journal/une revue › Article de revue › Revue par des pairs

Résumé

Tumor-infiltrating T lymphocytes (TILs) are observed in a number of human primary or metastatic tumors. Recently, gene expression profiling experiments suggested that the presence of T cells in metastatic melanomas before vaccinating the patients with tumor antigens could be a biomarker for clinical benefit from the vaccines. In this context, we review results pertaining to TILs in human melanomas, their prognostic value, and some possible reasons why their presence could help in selecting melanoma patients for vaccination against tumor-specific antigens.

langue originale	Anglais
Pages (de - à)	1153-1160
Nombre de pages	8
journal	Cancer Immunology, Immunotherapy
Volume	60
Numéro de publication	8
Les DOIs	https://doi.org/10.1007/s00262-011-1026-2
Etat de la publication	Publié - août 2011
Modification externe	Oui

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10.1007/s00262-011-1026-2

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Absence of recognition of common melanocytic antigens by T cells isolated from the cerebrospinal fluid of a Vogt-Koyanagi-Harada patient
Abad, S., Wieërs, G., Colau, D., Wildmann, C., Delair, E., Dhote, R., Brézin, A. P., Kawakami, Y., Coulie, P. G. & van der Bruggen, P., 2 juil. 2014, Dans: Molecular Vision. 20, p. 956-969 14 p.
Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

Contient cette citation

@article{27c734e608e44dee82b715a1d26a1e0b,

title = "Tumor-infiltrating lymphocytes: Apparently good for melanoma patients. but why?",

abstract = "Tumor-infiltrating T lymphocytes (TILs) are observed in a number of human primary or metastatic tumors. Recently, gene expression profiling experiments suggested that the presence of T cells in metastatic melanomas before vaccinating the patients with tumor antigens could be a biomarker for clinical benefit from the vaccines. In this context, we review results pertaining to TILs in human melanomas, their prognostic value, and some possible reasons why their presence could help in selecting melanoma patients for vaccination against tumor-specific antigens.",

keywords = "Immunotherapy, Melanoma, PIVAC 10, Prognosis, T lymphocyte",

author = "Arcadi Cipponi and Gr{\'e}goire Wie{\"e}rs and \{Van Baren\}, Nicolas and Coulie, \{Pierre G.\}",

year = "2011",

month = aug,

doi = "10.1007/s00262-011-1026-2",

language = "English",

volume = "60",

pages = "1153--1160",

journal = "Cancer Immunology, Immunotherapy",

issn = "0340-7004",

publisher = "Springer Science and Business Media Deutschland GmbH",

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}

TY - JOUR

T1 - Tumor-infiltrating lymphocytes

T2 - Apparently good for melanoma patients. but why?

AU - Cipponi, Arcadi

AU - Wieërs, Grégoire

AU - Van Baren, Nicolas

AU - Coulie, Pierre G.

PY - 2011/8

Y1 - 2011/8

N2 - Tumor-infiltrating T lymphocytes (TILs) are observed in a number of human primary or metastatic tumors. Recently, gene expression profiling experiments suggested that the presence of T cells in metastatic melanomas before vaccinating the patients with tumor antigens could be a biomarker for clinical benefit from the vaccines. In this context, we review results pertaining to TILs in human melanomas, their prognostic value, and some possible reasons why their presence could help in selecting melanoma patients for vaccination against tumor-specific antigens.

AB - Tumor-infiltrating T lymphocytes (TILs) are observed in a number of human primary or metastatic tumors. Recently, gene expression profiling experiments suggested that the presence of T cells in metastatic melanomas before vaccinating the patients with tumor antigens could be a biomarker for clinical benefit from the vaccines. In this context, we review results pertaining to TILs in human melanomas, their prognostic value, and some possible reasons why their presence could help in selecting melanoma patients for vaccination against tumor-specific antigens.

KW - Immunotherapy

KW - Melanoma

KW - PIVAC 10

KW - Prognosis

KW - T lymphocyte

UR - https://www.scopus.com/pages/publications/79960914401

U2 - 10.1007/s00262-011-1026-2

DO - 10.1007/s00262-011-1026-2

M3 - Review article

C2 - 21553145

AN - SCOPUS:79960914401

SN - 0340-7004

VL - 60

SP - 1153

EP - 1160

JO - Cancer Immunology, Immunotherapy

JF - Cancer Immunology, Immunotherapy

IS - 8

ER -

Tumor-infiltrating lymphocytes: Apparently good for melanoma patients. but why?

Résumé

SDG des Nations Unies

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Résultat de recherche

Absence of recognition of common melanocytic antigens by T cells isolated from the cerebrospinal fluid of a Vogt-Koyanagi-Harada patient

Contient cette citation