Tumor-infiltrating lymphocytes: Apparently good for melanoma patients. but why?

Arcadi Cipponi, Grégoire Wieërs, Nicolas Van Baren, Pierre G. Coulie

Résultats de recherche: Contribution à un journal/une revueArticle de revueRevue par des pairs

Résumé

Tumor-infiltrating T lymphocytes (TILs) are observed in a number of human primary or metastatic tumors. Recently, gene expression profiling experiments suggested that the presence of T cells in metastatic melanomas before vaccinating the patients with tumor antigens could be a biomarker for clinical benefit from the vaccines. In this context, we review results pertaining to TILs in human melanomas, their prognostic value, and some possible reasons why their presence could help in selecting melanoma patients for vaccination against tumor-specific antigens.

langue originaleAnglais
Pages (de - à)1153-1160
Nombre de pages8
journalCancer Immunology, Immunotherapy
Volume60
Numéro de publication8
Les DOIs
Etat de la publicationPublié - août 2011
Modification externeOui

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