Résumé
The majority of cancer-associated deaths are related to secondary tumor formation. This multistep process involves the migration of cancer cells to anatomically distant organs. Metastasis formation relies on cancer cell dissemination and survival in the circulatory system, as well as adaptation to the new tissue notably through genetic and/or epigenetic alterations. A large number of proteins are clearly identified to play a role in the metastatic process but the structures and modes of action of these proteins are essentially unknown or poorly described. In this review, we detail the involvement of members of the transmembrane (TMEM) protein family in the formation of metastases or in the mechanisms leading to cancer cell dissemination such as migration and extra-cellular matrix remodelling. While the phenotype associated with TMEM over or down-expression is clear, the mechanisms by which these proteins allow cancer cell spreading remain, for most of them, unclear. In parallel, the 3D structures of these proteins are presented. Moreover, we proposed that TMEM proteins could be used as prognostic markers in different types of cancers and could represent potential targets for cancer treatment. A better understanding of this heterogeneous family of poorly characterized proteins thus opens perspectives for better cancer patient care.
| langue originale | Anglais |
|---|---|
| journal | Seminars in cancer biology |
| Les DOIs | |
| état | Publié - 2019 |
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Transmembrane (TMEM) protein family members : Poorly characterized even if essential for the metastatic process. / Marx, Sébastien; Dal Maso, Thomas; Chen, Jia Wei; Bury, Marina; Wouters, Johan; Michiels, Carine; Le Calvé, Benjamin.
Dans: Seminars in cancer biology, 2019.Résultats de recherche: Contribution à un journal/une revue › Article de revue
TY - JOUR
T1 - Transmembrane (TMEM) protein family members
T2 - Poorly characterized even if essential for the metastatic process
AU - Marx, Sébastien
AU - Dal Maso, Thomas
AU - Chen, Jia Wei
AU - Bury, Marina
AU - Wouters, Johan
AU - Michiels, Carine
AU - Le Calvé, Benjamin
N1 - Copyright © 2019. Published by Elsevier Ltd.
PY - 2019
Y1 - 2019
N2 - The majority of cancer-associated deaths are related to secondary tumor formation. This multistep process involves the migration of cancer cells to anatomically distant organs. Metastasis formation relies on cancer cell dissemination and survival in the circulatory system, as well as adaptation to the new tissue notably through genetic and/or epigenetic alterations. A large number of proteins are clearly identified to play a role in the metastatic process but the structures and modes of action of these proteins are essentially unknown or poorly described. In this review, we detail the involvement of members of the transmembrane (TMEM) protein family in the formation of metastases or in the mechanisms leading to cancer cell dissemination such as migration and extra-cellular matrix remodelling. While the phenotype associated with TMEM over or down-expression is clear, the mechanisms by which these proteins allow cancer cell spreading remain, for most of them, unclear. In parallel, the 3D structures of these proteins are presented. Moreover, we proposed that TMEM proteins could be used as prognostic markers in different types of cancers and could represent potential targets for cancer treatment. A better understanding of this heterogeneous family of poorly characterized proteins thus opens perspectives for better cancer patient care.
AB - The majority of cancer-associated deaths are related to secondary tumor formation. This multistep process involves the migration of cancer cells to anatomically distant organs. Metastasis formation relies on cancer cell dissemination and survival in the circulatory system, as well as adaptation to the new tissue notably through genetic and/or epigenetic alterations. A large number of proteins are clearly identified to play a role in the metastatic process but the structures and modes of action of these proteins are essentially unknown or poorly described. In this review, we detail the involvement of members of the transmembrane (TMEM) protein family in the formation of metastases or in the mechanisms leading to cancer cell dissemination such as migration and extra-cellular matrix remodelling. While the phenotype associated with TMEM over or down-expression is clear, the mechanisms by which these proteins allow cancer cell spreading remain, for most of them, unclear. In parallel, the 3D structures of these proteins are presented. Moreover, we proposed that TMEM proteins could be used as prognostic markers in different types of cancers and could represent potential targets for cancer treatment. A better understanding of this heterogeneous family of poorly characterized proteins thus opens perspectives for better cancer patient care.
UR - http://www.scopus.com/inward/record.url?scp=85071337659&partnerID=8YFLogxK
U2 - 10.1016/j.semcancer.2019.08.018
DO - 10.1016/j.semcancer.2019.08.018
M3 - Review article
C2 - 31454669
JO - Seminars in cancer biology
JF - Seminars in cancer biology
SN - 1044-579X
ER -