Résultat de recherche par an
Résultat de recherche par an
Résultats de recherche: Contribution à un journal/une revue › Article de revue › Revue par des pairs
Mitochondria fulfil a plethora of cellular functions ranging from energy production to regulation of inflammation and cell death control. The fundamental role of mitochondria makes them a target of choice for invading pathogens, with either an intracellular or extracellular lifestyle. Indeed, the modulation of mitochondrial functions by several bacterial pathogens has been shown to be beneficial for bacterial survival inside their host. However, so far, relatively little is known about the importance of mitochondrial recycling and degradation pathways through mitophagy in the outcome (success or failure) of bacterial infection. On the one hand, mitophagy could be considered as a defensive response triggered by the host upon infection to maintain mitochondrial homeostasis. However, on the other hand, the pathogen itself may initiate the host mitophagy to escape from mitochondrial-mediated inflammation or antibacterial oxidative stress. In this review, we will discuss the diversity of various mechanisms of mitophagy in a general context, as well as what is currently known about the different bacterial pathogens that have developed strategies to manipulate the host mitophagy.
langue originale | Anglais |
---|---|
Numéro d'article | e1011471 |
Nombre de pages | 19 |
journal | Plos Pathogens |
Volume | 19 |
Numéro de publication | 7 July |
Les DOIs | |
Etat de la publication | Publié - 6 juil. 2023 |
Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs
Arnould, T. (Responsable du Projet)
1/01/20 → 31/12/21
Projet: Recherche
De Bolle, X. (!!Manager)
Plateforme technologique Laboratoire de securite biologique au niveau 3Equipement/installations: Plateforme technolgique
Student thesis: Doc types › Docteur en Sciences