TLR2 and TLR4 activate p38 MAPK and JNK during endurance exercise in skeletal muscle

Hermann Zbinden-Foncea, Jean-Marc Raymackers, Louise Deldicque, Patricia Renard, Marc Francaux

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

Résumé

Toll-like receptors 2 and 4 (TLR2, TLR4) are found in the membrane of skeletal muscle cells. A variety of molecular components can activate TLR2 and TLR4, among others, long-chain fatty acids. The subsequent downstream signaling triggers the mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) pathways. Therefore, the purpose of this study was to test whether an elevation of extracellular nonesterified fatty acids (NEFA) observed during endurance exercise may activate the MAPK and NF-κB pathways via TLR2 and TLR4.
langue originaleAnglais
Pages (de - à)1463-72
Nombre de pages10
journalMedicine and science in sports and exercise
Volume44
Numéro de publication8
Les DOIs
Etat de la publicationPublié - août 2012

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