The Yersinia Yop virulon, a bacterial system to subvert cells of the primary host defense

    Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs


    The Yop virulon enables yersinias (Yersinia pestis, Y. pseudotuberculosis and Y. enterocolitica) to survive and multiply in the lymphoid tissues of their host. It is an integrated system allowing extracellular bacteria to communicate with the host cell's cytosol by injection of effector proteins. It is composed of four elements: (1) a contact or type III secretion system called Ysc, devoted to the secretion of Yop proteins. This secretion apparatus, made of some 22 proteins, recognizes the Yops by a short N-terminal signal that is not cleaved off during secretion; (2) a system designed to deliver bacterial proteins into eukaryotic target cells. This system is made of YopB, YopD and LcrV; (3) a control element (YopN) and (4) a set of effector Yop proteins designed to disarm these cells or disrupt their communications (YopE, YopH, YopM, YpkA/YopO, YopP). The whole virulon is encoded by a 70-kb plasmid called pYV. Transcription of the genes is controlled both by temperature and by contact with a eukaryotic cell.
    langue originaleAnglais
    Pages (de - à)253-61
    Nombre de pages9
    journalFolia microbiologica
    Numéro de publication3
    Etat de la publicationPublié - 1998

    Empreinte digitale

    Examiner les sujets de recherche de « The Yersinia Yop virulon, a bacterial system to subvert cells of the primary host defense ». Ensemble, ils forment une empreinte digitale unique.

    Contient cette citation