The role of thioredoxin reductase in gold nanoparticle radiosensitization effects

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Résumé

AIM: To identify new mechanisms responsible for the radiosensitization effect of gold nanoparticles (GNPs).

MATERIALS & METHODS: A549 lung carcinoma cells were incubated with 10-nm GNPs during 6 or 24 h before to be exposed to 25 keV/μm protons or 225 kV x-rays.

RESULTS: GNP incubation led to a time-dependent mitochondria membrane depolarization, oxidative stress and to x-ray and proton radiosensitization. Moreover, a marked inhibition of thioredoxin reductase was observed. Irradiation of cells invalidated for thioredoxin reductase evidenced a radiosensitization effect, suggesting that this enzyme is a potential GNP target.

CONCLUSION: We suggest that GNPs play a radiosensitizer role by weakening detoxification systems. Altogether, these results open up promising novel strategies for the development of nanotechnologies associated to radiotherapy.

langue originaleAnglais
Pages (de - à)2917-2937
Nombre de pages21
journalNanomedicine
Volume13
Numéro de publication22
Date de mise en ligne précoce2018
Les DOIs
Etat de la publicationPublié - 1 nov. 2018
Modification externeOui

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