The role of fluids in high-pressure polymorphism of drugs: Different behaviour of β-chlorpropamide in different inert gas and liquid media

B. A. Zakharov, Y. V. Seryotkin, N. A. Tumanov, D. Paliwoda, M. Hanfland, A. V. Kurnosov, E. V. Boldyreva

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    Résumé

    The hydrostatic compression of β-chlorpropamide gives different high-pressure phases, depending on the choice of pressure-transmitting fluid (paraffin, neon and helium). This is particularly surprising as none of these fluids interact obviously with the solid at ambient pressure. This phenomenon is not related to dissolution and recrystallization, in contrast to what has been previously observed for β-chlorpropamide in a 1:1 pentane-isopentane mixture.

    langue originaleAnglais
    Pages (de - à)92629-92637
    Nombre de pages9
    journalRSC Advances
    Volume6
    Numéro de publication95
    Les DOIs
    Etat de la publicationPublié - 28 sept. 2016

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