The role of fluids in high-pressure polymorphism of drugs: Different behaviour of β-chlorpropamide in different inert gas and liquid media

B. A. Zakharov, Y. V. Seryotkin, N. A. Tumanov, D. Paliwoda, M. Hanfland, A. V. Kurnosov, E. V. Boldyreva

Résultats de recherche: Contribution à un journal/une revueArticle

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Résumé

The hydrostatic compression of β-chlorpropamide gives different high-pressure phases, depending on the choice of pressure-transmitting fluid (paraffin, neon and helium). This is particularly surprising as none of these fluids interact obviously with the solid at ambient pressure. This phenomenon is not related to dissolution and recrystallization, in contrast to what has been previously observed for β-chlorpropamide in a 1:1 pentane-isopentane mixture.

langue originaleAnglais
Pages (de - à)92629-92637
Nombre de pages9
journalRSC Advances
Volume6
Numéro de publication95
Les DOIs
étatPublié - 28 sept. 2016

Empreinte digitale

Chlorpropamide
Noble Gases
Inert gases
Polymorphism
Fluids
Liquids
Pharmaceutical Preparations
Neon
Helium
Paraffin
Paraffins
Dissolution
Compaction
Crystallization

Citer ceci

Zakharov, B. A. ; Seryotkin, Y. V. ; Tumanov, N. A. ; Paliwoda, D. ; Hanfland, M. ; Kurnosov, A. V. ; Boldyreva, E. V. / The role of fluids in high-pressure polymorphism of drugs: Different behaviour of β-chlorpropamide in different inert gas and liquid media. Dans: RSC Advances. 2016 ; Vol 6, Numéro 95. p. 92629-92637.
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The role of fluids in high-pressure polymorphism of drugs: Different behaviour of β-chlorpropamide in different inert gas and liquid media. / Zakharov, B. A.; Seryotkin, Y. V.; Tumanov, N. A.; Paliwoda, D.; Hanfland, M.; Kurnosov, A. V.; Boldyreva, E. V.

Dans: RSC Advances, Vol 6, Numéro 95, 28.09.2016, p. 92629-92637.

Résultats de recherche: Contribution à un journal/une revueArticle

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