The long-term chemical stability of injectable drugs reconstituted in Hospital Pharmacy

Jean-Daniel Hecq, Marie Godet, Jacques Jamart, Benoît Bihin, Laurence Galanti

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs



Other injectable preparations than parenteral nutrition admixture and injectable cytotoxic drugs could be prepared by Centralised IntraVenous Admixture Service (CIVAS) if the Long-term stability of the drugs is known. However, this information is not always available.

To develop a program of chemical drug stability analysis in collaboration between Hospital Pharmacy, Medical Laboratory and Scientific Support Unit to determine the long-term stability of largely used injectable anti-infectious and non-anti-infectious drugs.

After a setup of the High Performance Liquid Chromatography (HPLCI method, 28 drugs were reconstituted in laminar air flow hood, 17 of them stored directly at 5 +/- 3 degrees C and 19 stored in the freezer at -20 degrees C, thawed by microwave following a standardised procedure and stored at 5 +/- 3 degrees C before use. Concentration stability was evaluated by regression analysis.

For each drug, long-term stability has varied from 11 days to 180 days. The freeze-thaw treatment by microwave may enhance the stability (from 30 to 120 days) and allow batch-scale production of intravenous drugs, less expensive in term of manpower and sterile device than a drug reconstitution at the ward. The results were published by 55 posters in international congress and by 36 publications in national and international pharmaceutical journals.

Our findings contribute to enhance the scale of drugs that may be take on by a CIVAS.
langue originaleFrançais
Pages (de - à)36-44
journalJ. Pharm. Belg.
Numéro de publication3
Etat de la publicationPublié - sept. 2015
Modification externeOui

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