The effects of vitamin d on skeletal muscle strength, muscle mass, and muscle power: A systematic review and meta-analysis of randomized controlled trials

Charlotte Beaudart, Fanny Buckinx, Véronique Rabenda, Sophie Gillain, Etienne Cavalier, Justine Slomian, Jean Petermans, Jean Yves Reginster, Olivier Bruyère

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Résumé

Context: There is growing evidence that vitamin D plays a role on several tissues including skeletal muscle.

Objective: The aim was to summarize with a meta-analysis, the effects of vitamin D supplementation on muscle function.

Data Sources: Asystematic research of randomized controlled trials, performed between 1966 and January 2014 has been conducted on Medline, Cochrane Database of Systematics Reviews, Cochrane Central Register of Controlled and completed by a manual review of the literature and congressional abstracts.

Study Selection: All forms and doses of vitamin D supplementation, with or without calcium supplementation, compared with placebo or control were included. Out of the 225 potentially relevant articles, 30 randomized controlled trials involving 5615 individuals (mean age: 61.1 years) met the inclusion criteria.

Data Extraction: Data were extracted by two independent reviewers.

Data Synthesis: Results revealed a small but significant positive effect of vitamin D supplementation on global muscle strength with a standardized mean difference (SMD) of 0.17 (P = .02). No significant effect was found on muscle mass (SMD 0.058; P = .52) or muscle power (SMD 0.057; P =.657). Results on muscle strength were significantly more important with people who presented a 25-hydroxyvitamin D level >30 nmol/L. Supplementation seems also more effective on people aged 65 years or older compared to younger subjects (SMD 0.25; 95% CI 0.01 to 0.48 vs SMD 0.03; 95% CI-0.08 to 0.14).

Conclusions: Vitamin D supplementation has a small positive impact on muscle strength, but additional studies are needed to define optimal treatment modalities, including dose, mode of administration, and duration.

langue originaleAnglais
Pages (de - à)4336-4345
Nombre de pages10
journalJournal of Clinical Endocrinology and Metabolism
Volume99
Numéro de publication11
Les DOIs
Etat de la publicationPublié - 1 nov. 2014
Modification externeOui

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