The DOAC (direct oral anticoagulant) Dipstick reliably excludes residual FXa inhibitors levels in the preoperative setting

Julie Vassart; Alfonso Tafur; Marisa Durante; Anne-Yseult Boucher; Laure Morimont; Jeanine Walenga; Job F. Harenberg; Jonathan Douxfils

doi:10.1016/j.thromres.2024.04.029

The DOAC (direct oral anticoagulant) Dipstick reliably excludes residual FXa inhibitors levels in the preoperative setting

Julie Vassart
, Alfonso Tafur
, Marisa Durante
, Anne-Yseult Boucher
, Laure Morimont
, Jeanine Walenga
, Job F. Harenberg
, Jonathan Douxfils

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

Résumé

Highlights
- Preoperative point-of-care test to determine DOAC levels in plasma
- Comparison of the performance of a point-of-care test, UHPLC-MS/MS and a chromogenic assay
- A negative DOAC Dipstick excludes residual levels of FXa inhibitors in plasma.
- Reference standard test significantly impacts the performance of the index test.
- Chromogenic anti-FXa assays should be validated against UHPLC-MS/MS.

langue originale	Anglais
Numéro d'article	109023
journal	Thrombosis Research
Volume	239
Numéro de publication	July 2024
Les DOIs	https://doi.org/10.1016/j.thromres.2024.04.029
Etat de la publication	Publié - juil. 2024

Financement

This work was partially supported by Doasense GmbH, Germany, by the NorthShore Vascular Medicine Research fund, and by the Cardiovascular Research Institute of Loyola University Chicago.

Bailleurs de fonds
DOASENSE GmbH
NorthShore Vascular
Cardiovascular Research Institute of Loyola University Chicago

Accès au document

10.1016/j.thromres.2024.04.029

Autres fichiers et liens

Lien vers la publication sur Scopus

Clinical Pharmacology Research Group
Douxfils, J. (Promoteur), Dogné, J.-M. (Promoteur), Musuamba Tshinanu, F. (Promoteur), Masereel, B. (Promoteur), Wieërs, G. (Promoteur), Haguet, H. (Chercheur), RONVAUX, L. (Chercheur), Donis, N. (Chercheur), Morimont, L. (Chercheur), Evrard, J. (Chercheur), Siriez, R. (Chercheur), Gillot, C. (Chercheur), Favresse, J. (Chercheur), BOUVY, C. (Chercheur), Djokoto, H. (Chercheur), Didembourg, M. (Chercheur), David, C. (Rôle de support), Melchionda, S. (Rôle de support), Maloteau, V. (Technicien), Boucher, A.-Y. (Technicien), Devel, P. (Technicien), Modaffari, E. (Technicien), Vandeputte, M. (Technicien), De Messemaeker, A. (Secrétaire), Decarpentrie, J. (Chercheur), Vassart, J. (Chercheur) & De Groote, A. (Chercheur)
1/04/22 → …
Projet: Axe de recherche
The BIOCOAG project : Biological assessment of the control of anticoagulation
Douxfils, J. (Responsable du Projet), Mullier, F. (Co-investigateur), Dogné, J.-M. (Co-investigateur), Siriez, R. (Chercheur), Evrard, J. (Chercheur) & Vassart, J. (Chercheur)
1/09/11 → …
Projet: Recherche

Contient cette citation

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abstract = "Highlights - Preoperative point-of-care test to determine DOAC levels in plasma - Comparison of the performance of a point-of-care test, UHPLC-MS/MS and a chromogenic assay - A negative DOAC Dipstick excludes residual levels of FXa inhibitors in plasma. - Reference standard test significantly impacts the performance of the index test. - Chromogenic anti-FXa assays should be validated against UHPLC-MS/MS.",

author = "Julie Vassart and Alfonso Tafur and Marisa Durante and Anne-Yseult Boucher and Laure Morimont and Jeanine Walenga and Harenberg, \{Job F.\} and Jonathan Douxfils",

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AU - Tafur, Alfonso

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AU - Morimont, Laure

AU - Walenga, Jeanine

AU - Harenberg, Job F.

AU - Douxfils, Jonathan

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AB - Highlights - Preoperative point-of-care test to determine DOAC levels in plasma - Comparison of the performance of a point-of-care test, UHPLC-MS/MS and a chromogenic assay - A negative DOAC Dipstick excludes residual levels of FXa inhibitors in plasma. - Reference standard test significantly impacts the performance of the index test. - Chromogenic anti-FXa assays should be validated against UHPLC-MS/MS.

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JF - Thrombosis Research

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M1 - 109023

ER -

The DOAC (direct oral anticoagulant) Dipstick reliably excludes residual FXa inhibitors levels in the preoperative setting

Résumé

Financement

Accès au document

Autres fichiers et liens

Empreinte digitale

Projets

Clinical Pharmacology Research Group

The BIOCOAG project : Biological assessment of the control of anticoagulation

Contient cette citation