The DOAC (direct oral anticoagulant) Dipstick reliably excludes residual FXa inhibitors levels in the preoperative setting

Julie Vassart; Alfonso Tafur; Marisa Durante; Anne-Yseult Boucher; Laure Morimont; Jeanine Walenga; Job F. Harenberg; Jonathan Douxfils

doi:10.1016/j.thromres.2024.04.029

The DOAC (direct oral anticoagulant) Dipstick reliably excludes residual FXa inhibitors levels in the preoperative setting

Julie Vassart, Alfonso Tafur, Marisa Durante, Anne-Yseult Boucher, Laure Morimont, Jeanine Walenga, Job F. Harenberg, Jonathan Douxfils

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

Résumé

Highlights
- Preoperative point-of-care test to determine DOAC levels in plasma
- Comparison of the performance of a point-of-care test, UHPLC-MS/MS and a chromogenic assay
- A negative DOAC Dipstick excludes residual levels of FXa inhibitors in plasma.
- Reference standard test significantly impacts the performance of the index test.
- Chromogenic anti-FXa assays should be validated against UHPLC-MS/MS.

langue originale	Anglais
Numéro d'article	109023
journal	Thrombosis Research
Volume	239
Numéro de publication	July 2024
Les DOIs	https://doi.org/10.1016/j.thromres.2024.04.029
Etat de la publication	Publié - juil. 2024

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10.1016/j.thromres.2024.04.029

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abstract = "Highlights- Preoperative point-of-care test to determine DOAC levels in plasma- Comparison of the performance of a point-of-care test, UHPLC-MS/MS and a chromogenic assay- A negative DOAC Dipstick excludes residual levels of FXa inhibitors in plasma.- Reference standard test significantly impacts the performance of the index test. - Chromogenic anti-FXa assays should be validated against UHPLC-MS/MS.",

author = "Julie Vassart and Alfonso Tafur and Marisa Durante and Anne-Yseult Boucher and Laure Morimont and Jeanine Walenga and Harenberg, {Job F.} and Jonathan Douxfils",

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AU - Vassart, Julie

AU - Tafur, Alfonso

AU - Durante, Marisa

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AU - Morimont, Laure

AU - Walenga, Jeanine

AU - Harenberg, Job F.

AU - Douxfils, Jonathan

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AB - Highlights- Preoperative point-of-care test to determine DOAC levels in plasma- Comparison of the performance of a point-of-care test, UHPLC-MS/MS and a chromogenic assay- A negative DOAC Dipstick excludes residual levels of FXa inhibitors in plasma.- Reference standard test significantly impacts the performance of the index test. - Chromogenic anti-FXa assays should be validated against UHPLC-MS/MS.

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JF - Thrombosis Research

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The DOAC (direct oral anticoagulant) Dipstick reliably excludes residual FXa inhibitors levels in the preoperative setting

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