Synthesis of Tertiary Enamides by Ag2CO3-Promoted Pd-Catalyzed Alkenylation of Acyclic Secondary Amides

Résultats de recherche: Contribution à un journal/une revueArticle

Résumé

A Pd-catalyzed methodology for the preparation of tertiary enamides from acyclic secondary amides and bromo acrylates under mild reaction conditions has been developed using [Pd2(dba)3], XantPhos, and Ag2CO3 as a base. The reaction occurs through a stereospecific metal-mediated oxidative-insertion mechanism.

langue originaleAnglais
Pages (de - à)4844-4847
Nombre de pages4
journalOrganic Letters
Volume18
Numéro de publication19
Les DOIs
étatPublié - 7 oct. 2016

Empreinte digitale

Alkenylation
Acrylates
Amides
amides
Metals
synthesis
acrylates
insertion
methodology
preparation
metals
xantphos

Citer ceci

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title = "Synthesis of Tertiary Enamides by Ag2CO3-Promoted Pd-Catalyzed Alkenylation of Acyclic Secondary Amides",
abstract = "A Pd-catalyzed methodology for the preparation of tertiary enamides from acyclic secondary amides and bromo acrylates under mild reaction conditions has been developed using [Pd2(dba)3], XantPhos, and Ag2CO3 as a base. The reaction occurs through a stereospecific metal-mediated oxidative-insertion mechanism.",
author = "Arnaud Delforge and Irene Georgiou and Adrian Kremer and Johan Wouters and Davide Bonifazi",
year = "2016",
month = "10",
day = "7",
doi = "10.1021/acs.orglett.6b02305",
language = "English",
volume = "18",
pages = "4844--4847",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "19",

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T1 - Synthesis of Tertiary Enamides by Ag2CO3-Promoted Pd-Catalyzed Alkenylation of Acyclic Secondary Amides

AU - Delforge, Arnaud

AU - Georgiou, Irene

AU - Kremer, Adrian

AU - Wouters, Johan

AU - Bonifazi, Davide

PY - 2016/10/7

Y1 - 2016/10/7

N2 - A Pd-catalyzed methodology for the preparation of tertiary enamides from acyclic secondary amides and bromo acrylates under mild reaction conditions has been developed using [Pd2(dba)3], XantPhos, and Ag2CO3 as a base. The reaction occurs through a stereospecific metal-mediated oxidative-insertion mechanism.

AB - A Pd-catalyzed methodology for the preparation of tertiary enamides from acyclic secondary amides and bromo acrylates under mild reaction conditions has been developed using [Pd2(dba)3], XantPhos, and Ag2CO3 as a base. The reaction occurs through a stereospecific metal-mediated oxidative-insertion mechanism.

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U2 - 10.1021/acs.orglett.6b02305

DO - 10.1021/acs.orglett.6b02305

M3 - Article

AN - SCOPUS:84990859062

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SP - 4844

EP - 4847

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

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