Synthesis of Novel Ferrocene-Benzofuran Hybrids via Palladium- and Copper-Catalyzed Reactions

Enikő Nagy, Márk Váradi, Zoltán Nagymihály, László Kollár, Krisztina Kovács, Kitti Andreidesz, Ágnes Gömöry, Nikolay Tumanov, Johan Wouters, Rita Skoda-Földes

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Résumé

The combination of the ferrocene skeleton with pharmacophores often leads to molecules with interesting biological properties. Five ferrocene-benzofuran hybrids of different structures were synthesized by transition metal catalyzed reactions. The efficiency of both homogeneous and heterogeneous catalytic methods was tested. The products were characterized using 1H, 13C NMR and FTIR spectroscopy, HRMS and cyclic voltammetry. The structure of one of the new compounds was also proved with X-ray crystallography. The new hybrids showed moderate cytotoxicity on MCF-7 and MDA-MB-231 cell lines. It is remarkable that the less curable MDA-MB-231 cell line was more sensitive to treatment with three ferrocene derivatives.
langue originaleAnglais
Numéro d'article205
Pages (de - à)205
Nombre de pages16
journalInorganics
Volume10
Numéro de publication11
Les DOIs
Etat de la publicationPublié - 11 nov. 2022

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