Résumé
exo-Glycals are both valuable synthetic tools and biologically relevant structures. This article reviews the novel synthetic approaches that have been reported to synthesize sugar based tri- or tetrasubstituted exocyclic enol ethers. Among those, the Julia modified olefinations as well as the transition metal catalyzed cross-couplings have been extensively developed. The synthesis of unprecedented fluorinated and sulfonylated phosphono-exo-glycals are also described. An overview of the biological applications in which exo-glycals acts as inhibitors or inactivator of relevant enzymes is finally presented.
langue originale | Anglais |
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Pages (de - à) | 6512-6519 |
Nombre de pages | 8 |
journal | Tetrahedron |
Volume | 74 |
Numéro de publication | 45 |
Les DOIs | |
Etat de la publication | Publié - 8 nov. 2018 |