Synthesis and evaluation of heterocycle structures as potential inhibitors of Mycobacterium tuberculosis UGM

Carine Maaliki, Jian Fu, Sydney Villaume, Albertus Viljoen, Clément Raynaud, Sokaina Hammoud, Jérôme Thibonnet, Laurent Kremer, Stéphane P. Vincent, Emilie Thiery

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

14 Téléchargements (Pure)

Résumé

In this study, we screen three heterocyclic structures as potential inhibitors of UDP-galactopyranose mutase (UGM), an enzyme involved in the biosynthesis of the cell wall of Mycobacterium tuberculosis. In order to understand the binding mode, docking simulations are performed on the best inhibitors. Their activity on Mycobacterium tuberculosis is also evaluated. This study made it possible to highlight an “oxazepino-indole” structure as a new inhibitor of UGM and of M. tuberculosis growth in vitro.

langue originaleAnglais
Numéro d'article115579
journalBioorganic and Medicinal Chemistry
Volume28
Numéro de publication13
Les DOIs
Etat de la publicationPublié - 1 juil. 2020

Empreinte digitale

Examiner les sujets de recherche de « Synthesis and evaluation of heterocycle structures as potential inhibitors of Mycobacterium tuberculosis UGM ». Ensemble, ils forment une empreinte digitale unique.

Contient cette citation