Synthesis and biological evaluation of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas

Bernard Masereel; R.b Ouedraogo; Jean-Michel Dogné; M.H. Antoine; Pascal De Tullio; Bernard Pirotte; Lionel Pochet; Jacques Delarge; P.b Lebrun

Synthesis and biological evaluation of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas

Bernard Masereel, R.b Ouedraogo, Jean-Michel Dogné, M.H. Antoine, Pascal De Tullio, Bernard Pirotte, Lionel Pochet, Jacques Delarge, P.b Lebrun

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

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Résumé

Sulfonylcyanoguanidines and sulfonamidonitroethylenes are bioisosteres of hypoglycemic sulfonylureas and were prepared and evaluated for their insulin release potency from rat pancreatic islets. At 25 μM, both bioisosteres of glibenclamide, sulfonylcyanoguanidine 22 and sulfonamidonitroethylene 23, were as patent as their parent on insulin secretion.

langue originale	Indéfini/inconnu
Pages (de - à)	453-456
Nombre de pages	4
journal	European Journal of Medicinal Chemistry
Volume	32
Numéro de publication	5
Etat de la publication	Publié - 1997

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lib_1997_eurjmedchem_32_453-456Version finale publiée, 228 KB

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@article{933a12f674c34090a5920956f0cdf8f8,

title = "Synthesis and biological evaluation of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas",

abstract = "Sulfonylcyanoguanidines and sulfonamidonitroethylenes are bioisosteres of hypoglycemic sulfonylureas and were prepared and evaluated for their insulin release potency from rat pancreatic islets. At 25 μM, both bioisosteres of glibenclamide, sulfonylcyanoguanidine 22 and sulfonamidonitroethylene 23, were as patent as their parent on insulin secretion.",

author = "Bernard Masereel and R.b Ouedraogo and Jean-Michel Dogn{\'e} and M.H. Antoine and {De Tullio}, Pascal and Bernard Pirotte and Lionel Pochet and Jacques Delarge and P.b Lebrun",

year = "1997",

language = "Ind{\'e}fini/inconnu",

volume = "32",

pages = "453--456",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

publisher = "Elsevier",

number = "5",

}

Synthesis and biological evaluation of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas. / Masereel, Bernard; Ouedraogo, R.b; Dogné, Jean-Michel et al.
Dans: European Journal of Medicinal Chemistry, Vol 32, Numéro 5, 1997, p. 453-456.

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

TY - JOUR

T1 - Synthesis and biological evaluation of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas

AU - Masereel, Bernard

AU - Ouedraogo, R.b

AU - Dogné, Jean-Michel

AU - Antoine, M.H.

AU - De Tullio, Pascal

AU - Pirotte, Bernard

AU - Pochet, Lionel

AU - Delarge, Jacques

AU - Lebrun, P.b

PY - 1997

Y1 - 1997

N2 - Sulfonylcyanoguanidines and sulfonamidonitroethylenes are bioisosteres of hypoglycemic sulfonylureas and were prepared and evaluated for their insulin release potency from rat pancreatic islets. At 25 μM, both bioisosteres of glibenclamide, sulfonylcyanoguanidine 22 and sulfonamidonitroethylene 23, were as patent as their parent on insulin secretion.

AB - Sulfonylcyanoguanidines and sulfonamidonitroethylenes are bioisosteres of hypoglycemic sulfonylureas and were prepared and evaluated for their insulin release potency from rat pancreatic islets. At 25 μM, both bioisosteres of glibenclamide, sulfonylcyanoguanidine 22 and sulfonamidonitroethylene 23, were as patent as their parent on insulin secretion.

M3 - Article

SN - 0223-5234

VL - 32

SP - 453

EP - 456

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 5

ER -