@article{d096bd2982c54b429fc22f69dd7abe23,
title = "Synthesis and biological evaluation of 3,4-dihydro-1H-[1,4] oxazepino [6,5,4-hi] indol-1-ones and 4,6-dihydrooxepino [5,4,3-cd] indol-1(3H)-ones as Mycobacterium tuberculosis inhibitors",
abstract = "This study focuses on the synthesis of 1,7- and 3,4-indole-fused lactones via a simple and efficient reaction sequence. The functionalization of these “oxazepino-indole” and “oxepino-indole” tricycles is carried out by palladium catalysed C[sbnd]C coupling, nucleophilic substitution or 1,3-dipolar cycloaddition. The evaluation of their activity against Mycobacterium tuberculosis shows that the “oxazepino-indole” structure is a new inhibitor of M. tuberculosis growth in vitro.",
keywords = "Heterocycles, Indoles, Inhibitor, Mycobacterium tuberculosis",
author = "Bastien Champciaux and Cl{\'e}ment Raynaud and Albertus Viljoen and Lo{\"i}c Chene and J{\'e}r{\^o}me Thibonnet and Vincent, {St{\'e}phane P.} and Laurent Kremer and Emilie Thiery",
note = "Funding Information: We acknowledge the French Ministry for Research and Innovation for the financial support and Dr. Fr{\'e}d{\'e}ric Montigny (Analysis Department, Tours University) for HRMS. This study was supported by the Fondation pour la Recherche M{\'e}dicale (grant DEQ20150331719 to L.K.), the Association Gregory Lemarchal and Vaincre la Mucoviscidose (grant RIF20180502320 to C.R.). Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",
year = "2021",
month = aug,
day = "1",
doi = "10.1016/j.bmc.2021.116248",
language = "English",
volume = "43",
journal = "Bioorganic and Medicinal Chemistry",
issn = "0968-0896",
publisher = "Elsevier Limited",
}
