Sustainable Approach to Waste-Minimized Sonogashira Cross-Coupling Reaction Based on Recoverable/Reusable Heterogeneous Catalytic/Base System and Acetonitrile Azeotrope

Vadym Kozell, Michael McLaughlin, Giacomo Strappaveccia, Stefano Santoro, Lucia Anna Bivona, Carmela Aprile, Michelangelo Gruttadauria, Luigi Vaccaro

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

Résumé

In this contribution, we present a chemically efficient and sustainable protocol for the palladium-catalyzed copper-free Sonogashira cross-coupling reaction, based on the use of a heterogeneous catalytic system. This consists in the combination of a palladium catalyst on highly cross-linked thiazolidine network on silica and a polystyrene-supported base. The solid catalyst/base system acts as a palladium scavenger avoiding leaching of the metal and consequent product contamination. The reaction can be conducted in safe and easily recoverable acetonitrile/water azeotrope as reaction medium. This proved to be an efficient greener alternative to the classic toxic aprotic media commonly used in cross-coupling reaction, such as DMF and NMP. Acetonitrile/water azeotrope could be easily recovered and reused allowing the minimization of waste production. Our approach, based on the use of both a supported base and a supported catalyst, has proven to be efficient for the waste reduction, as proved by the low E-factor values achieved.

langue originaleAnglais
Pages (de - à)7209-7216
Nombre de pages8
journalACS Sustainable Chemistry and Engineering
Volume4
Numéro de publication12
Les DOIs
Etat de la publicationPublié - 5 déc. 2016

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