Résumé
The design of selective COX-2 inhibitors is a new approach to obtain potent anti-inflammatory drugs but with less side-effects. Several families of such inhibitors were reported in literature. In this review, the drug design processes used to understand their binding mode and the origin of selectivity of these compounds are described.
langue originale | Anglais |
---|---|
Pages (de - à) | 603-615 |
Nombre de pages | 13 |
journal | Mini-reviews in medicinal chemistry |
Volume | 4 |
Etat de la publication | Publié - 2004 |