Stereospecific enzymic cyclization of a synthetic 2,3-oxidosqualene analogue bearing an 18Z carbon-carbon double bond

M. Hérin; P. Sandra; A. Krief

Stereospecific enzymic cyclization of a synthetic 2,3-oxidosqualene analogue bearing an 18Z carbon-carbon double bond

M. Hérin, P. Sandra, A. Krief

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Résumé

This report discloses the first successful cyclization of a squalene analogue bearing a Δ Z instead of E CC bond which leads to a lanosterol analogue possessing the unnatural 20S stereochemistry. The hypotheses of sterol biosynthesis are discussed in the light of these findings.

langue originale	Anglais
Pages (de - à)	3103-3106
Nombre de pages	4
journal	Tetrahedron Letters
Volume	20
Numéro de publication	33
Etat de la publication	Publié - 1 janv. 1979

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title = "Stereospecific enzymic cyclization of a synthetic 2,3-oxidosqualene analogue bearing an 18Z carbon-carbon double bond",

abstract = "This report discloses the first successful cyclization of a squalene analogue bearing a Δ Z instead of E CC bond which leads to a lanosterol analogue possessing the unnatural 20S stereochemistry. The hypotheses of sterol biosynthesis are discussed in the light of these findings.",

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year = "1979",

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T1 - Stereospecific enzymic cyclization of a synthetic 2,3-oxidosqualene analogue bearing an 18Z carbon-carbon double bond

AU - Hérin, M.

AU - Sandra, P.

AU - Krief, A.

PY - 1979/1/1

Y1 - 1979/1/1

N2 - This report discloses the first successful cyclization of a squalene analogue bearing a Δ Z instead of E CC bond which leads to a lanosterol analogue possessing the unnatural 20S stereochemistry. The hypotheses of sterol biosynthesis are discussed in the light of these findings.

AB - This report discloses the first successful cyclization of a squalene analogue bearing a Δ Z instead of E CC bond which leads to a lanosterol analogue possessing the unnatural 20S stereochemistry. The hypotheses of sterol biosynthesis are discussed in the light of these findings.

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M3 - Article

AN - SCOPUS:49249149565

SN - 0040-4039

VL - 20

SP - 3103

EP - 3106

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 33

ER -

Stereospecific enzymic cyclization of a synthetic 2,3-oxidosqualene analogue bearing an 18Z carbon-carbon double bond

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