TY - JOUR
T1 - Somatotrope GHRH/GH/IGF-1 axis at the crossroads between immunosenescence and frailty
AU - Bodart, Gwennaelle
AU - Goffinet, Lindsay
AU - Morrhaye, Gabriel
AU - Farhat, Khalil
AU - de Saint-Hubert, Marie
AU - Debacq-Chainiaux, Florence
AU - Swine, Christian
AU - Geenen, Vincent
AU - Martens, Henri J.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Immunosenescence, characterized by complex modifications of immunity with age, could be related to frailty syndrome in elderly individuals, leading to an inadequate response to minimal aggression. Functional decline (i.e., the loss of ability to perform activities of daily living) is related to frailty and decreased physiological reserves and is a frequent outcome of hospitalization in older patients. Links between immunosenescence and frailty have been explored and 20 immunological parameters, including insulin-like growth factor-1 (IGF-1), thymopoeisis, and telomere length, were shown to be affected in elderly patients with functional decline. A strong relationship between IGF-1 and thymic ouput was evidenced. IGF-1, a mediator of growth hormone (GH), was subsequently shown to induce interleukin-7 secretion in cultured primary human thymic epithelial cells. We are exploring the stress hypothesis in which an acute stressor is used as the discriminator of frailty susceptibility. GH can counteract the deleterious immunosuppressive effects of stress-induced steroids. Under nonstress conditions, the immunosenescent system preserves physiological responses, while under stress conditions, the combination of immunosenescence and a defect in the somatotrope axis might lead to functional decline.
AB - Immunosenescence, characterized by complex modifications of immunity with age, could be related to frailty syndrome in elderly individuals, leading to an inadequate response to minimal aggression. Functional decline (i.e., the loss of ability to perform activities of daily living) is related to frailty and decreased physiological reserves and is a frequent outcome of hospitalization in older patients. Links between immunosenescence and frailty have been explored and 20 immunological parameters, including insulin-like growth factor-1 (IGF-1), thymopoeisis, and telomere length, were shown to be affected in elderly patients with functional decline. A strong relationship between IGF-1 and thymic ouput was evidenced. IGF-1, a mediator of growth hormone (GH), was subsequently shown to induce interleukin-7 secretion in cultured primary human thymic epithelial cells. We are exploring the stress hypothesis in which an acute stressor is used as the discriminator of frailty susceptibility. GH can counteract the deleterious immunosuppressive effects of stress-induced steroids. Under nonstress conditions, the immunosenescent system preserves physiological responses, while under stress conditions, the combination of immunosenescence and a defect in the somatotrope axis might lead to functional decline.
KW - Aging
KW - Frailty
KW - GHRH
KW - Growth hormone
KW - Growth-hormone-releasing hormone
KW - IGF-1
KW - Immunosenescence
KW - Insulin-like growth factor-1
UR - http://www.scopus.com/inward/record.url?scp=84941811093&partnerID=8YFLogxK
U2 - 10.1111/nyas.12857
DO - 10.1111/nyas.12857
M3 - Article
AN - SCOPUS:84941811093
SN - 0077-8923
VL - 1351
SP - 61
EP - 67
JO - Annals of the New York academy of sciences
JF - Annals of the New York academy of sciences
IS - 1
ER -