Shape and structure controlling of calcium oxalate crystals by a combination of additives in the process of biomineralization

Nian Liu, Hao Xie, Hang Ping, Lin Wang, Zewen Liu, Fei Tao, Junhui Guo, Bao Lian Su

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs


The origin of complex hierarchical superstructures of biomaterials and their unique self-assembly mechanisms of formation are important in biological systems and have attracted considerable attention. In the present study, we investigated the morphological changes of calcium oxalate (CaOx) crystals induced by additives including chiral aspartic acid, sodium citrate, Mg2+, casein and combinations of these molecules. The morphology and structure of CaOx were identified with the use of various techniques. The morphogenesis of CaOx crystals were significantly affected by chiral aspartic acid, sodium citrate or Mg2+. However, they only formed calcium oxalate monohydrate (COM). It was observed that the chiral aspartic acid, sodium citrate and casein adhered to the surface of the crystals. The adherence of Mg2+ to crystals was not evident. Casein significantly affected the formation of COM and calcium oxalate dihydrate (COD). The ratio of different CaOx crystal forms is associated with the casein concentration. In combination with Mg2+ or citrate ions, casein showed improved formation of COD. The present study mimics biomineralization with a simple chemical approach and provides insight into the complicated system of CaOx biomineralization as well as facilitates the understanding of urinary stone treatment.

langue originaleAnglais
Pages (de - à)11014-11020
Nombre de pages7
journalRSC Advances
Numéro de publication20
Les DOIs
Etat de la publicationPublié - 1 janv. 2018

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