Selective detection of the antigenic polar heads of model lipid membranes supported on metals from their vibrational nonlinear optical response

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Résumé

We have investigated a metal-supported lipid film by using a sum frequency generation (SFG) spectrometer coupled to a free electron laser (FEL). DFT calculations on a molecular model have enabled to assign the vibrational signatures. The SFG vibrations detected in the backbone region, between 1375 cm and 1000 cm, originate from the vibrational motions of the 2,4-dinitrophenyl polar head of the lipid, which holds antigenic properties, and can therefore be used to selectively study the biological interactions with complementary antibodies. Theses results strengthen the role of SFG spectroscopy as a highly sensitive tool for biological detection.
langue originaleAnglais
Pages (de - à)12-15
Nombre de pages4
journalChemical Physics Letters
Volume489
Numéro de publication1-3
Les DOIs
étatPublié - 1 avr. 2010

Empreinte digitale

Membrane Lipids
lipids
Metals
membranes
Lipids
Free electron lasers
Discrete Fourier transforms
metals
Spectrometers
theses
Spectroscopy
antibodies
free electron lasers
Antibodies
signatures
spectrometers
vibration
spectroscopy
interactions

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title = "Selective detection of the antigenic polar heads of model lipid membranes supported on metals from their vibrational nonlinear optical response",
abstract = "We have investigated a metal-supported lipid film by using a sum frequency generation (SFG) spectrometer coupled to a free electron laser (FEL). DFT calculations on a molecular model have enabled to assign the vibrational signatures. The SFG vibrations detected in the backbone region, between 1375 cm and 1000 cm, originate from the vibrational motions of the 2,4-dinitrophenyl polar head of the lipid, which holds antigenic properties, and can therefore be used to selectively study the biological interactions with complementary antibodies. Theses results strengthen the role of SFG spectroscopy as a highly sensitive tool for biological detection.",
author = "D. Lis and J. Guthmuller and B. Champagne and C. Humbert and B. Busson and A. Tadjeddine and A. Peremans and F. Cecchet",
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T1 - Selective detection of the antigenic polar heads of model lipid membranes supported on metals from their vibrational nonlinear optical response

AU - Lis, D.

AU - Guthmuller, J.

AU - Champagne, B.

AU - Humbert, C.

AU - Busson, B.

AU - Tadjeddine, A.

AU - Peremans, A.

AU - Cecchet, F.

PY - 2010/4/1

Y1 - 2010/4/1

N2 - We have investigated a metal-supported lipid film by using a sum frequency generation (SFG) spectrometer coupled to a free electron laser (FEL). DFT calculations on a molecular model have enabled to assign the vibrational signatures. The SFG vibrations detected in the backbone region, between 1375 cm and 1000 cm, originate from the vibrational motions of the 2,4-dinitrophenyl polar head of the lipid, which holds antigenic properties, and can therefore be used to selectively study the biological interactions with complementary antibodies. Theses results strengthen the role of SFG spectroscopy as a highly sensitive tool for biological detection.

AB - We have investigated a metal-supported lipid film by using a sum frequency generation (SFG) spectrometer coupled to a free electron laser (FEL). DFT calculations on a molecular model have enabled to assign the vibrational signatures. The SFG vibrations detected in the backbone region, between 1375 cm and 1000 cm, originate from the vibrational motions of the 2,4-dinitrophenyl polar head of the lipid, which holds antigenic properties, and can therefore be used to selectively study the biological interactions with complementary antibodies. Theses results strengthen the role of SFG spectroscopy as a highly sensitive tool for biological detection.

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JF - Chemical Physics Letters

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