Selective detection of the antigenic polar heads of model lipid membranes supported on metals from their vibrational nonlinear optical response

D. Lis, J. Guthmuller, B. Champagne, C. Humbert, B. Busson, A. Tadjeddine, A. Peremans, F. Cecchet

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

Résumé

We have investigated a metal-supported lipid film by using a sum frequency generation (SFG) spectrometer coupled to a free electron laser (FEL). DFT calculations on a molecular model have enabled to assign the vibrational signatures. The SFG vibrations detected in the backbone region, between 1375 cm and 1000 cm, originate from the vibrational motions of the 2,4-dinitrophenyl polar head of the lipid, which holds antigenic properties, and can therefore be used to selectively study the biological interactions with complementary antibodies. Theses results strengthen the role of SFG spectroscopy as a highly sensitive tool for biological detection.
langue originaleAnglais
Pages (de - à)12-15
Nombre de pages4
journalChemical Physics Letters
Volume489
Numéro de publication1-3
Les DOIs
Etat de la publicationPublié - 1 avr. 2010

Empreinte digitale

Examiner les sujets de recherche de « Selective detection of the antigenic polar heads of model lipid membranes supported on metals from their vibrational nonlinear optical response ». Ensemble, ils forment une empreinte digitale unique.

Contient cette citation