Screening of senescence-associated genes with specific DNA array reveals the role of IGFBP-3 in premature senescence of human diploid fibroblasts

Florence Debacq-Chainiaux, Thierry Pascal, Emmanuelle Boilan, Coralie Bastin, Emilie Bauwens, Olivier Toussaint

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

Résumé

Repeated exposures to sublethal concentrations of tert-butylhydroperoxide and ethanol trigger premature senescence of WI-38 human diploid fibroblasts. We found 16 replicative senescence-related genes with similar alterations in expression level in replicative senescence and two models of stress-induced premature senescence. Among these genes was IGFBP-3. Using a siRNA approach, we showed that IGFBP-3 regulates the appearance of several biomarkers of senescence after repeated exposures of WI-38 fibroblasts to tert-butylhydroperoxide and ethanol. © 2008 Elsevier Inc. All rights reserved.

langue originaleAnglais
Pages (de - à)1817-1832
Nombre de pages16
journalFree Radical Biology and Medicine
Volume44
Numéro de publication10
Les DOIs
Etat de la publicationPublié - 15 mai 2008

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