@article{371d90345dc9405ca7b8a214eb7f378d,
title = "Scarless excision of an insertion sequence restores capsule production and virulence in Acinetobacter baumannii",
abstract = "We identify a new mechanism mediating capsule production and virulence in the WHO and CDC priority ESKAPE pathogen Acinetobacter baumannii. Non-capsulated and avirulent bacteria can revert into a capsulated and virulent state upon scarless excision of an ISAba13 insertion sequence under stress conditions. Reversion events fully restore capsule production and in vivo virulence. This increases our knowledge about A. baumannii genome dynamics, and the regulation of capsule production, virulence and resistance.",
author = "Cl{\'e}mence Whiteway and Adam Valcek and Chantal Philippe and Mojca Strazisar and {De Pooter}, Tim and Ivan Mateus and Anke Breine and {Van der Henst}, Charles",
note = "Funding Information: This project was supported by the Flanders Institute for Biotechnology (VIB) and has received funding from the European Union{\textquoteright}s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 748032 (CV). AB is recipient of a PhD fellowship Strategic Basic Research of the Research Foundation – Flanders (FWO, File number: 77258). Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = may,
doi = "10.1038/s41396-021-01179-3",
language = "English",
volume = "16",
pages = "1473--1477",
journal = "ISME Journal",
issn = "1751-7362",
publisher = "Nature Publishing Group",
number = "5",
}