Résumé
Background: Sarcopenia is increasingly recognized as a correlate of ageing and is associated with increased likelihood of adverse outcomes including falls, fractures, frailty and mortality. Several tools have been recommended to assess muscle mass, muscle strength and physical performance in clinical trials. Whilst these tools have proven to be accurate and reliable in investigational settings, many are not easily applied to daily practice. Methods: This paper is based on literature reviews performed by members of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) working group on frailty and sarcopenia. Face-to-face meetings were afterwards organized for the whole group to make amendments and discuss further recommendations. Results: This paper proposes some user-friendly and inexpensive methods that can be used to assess sarcopenia in real-life settings. Healthcare providers, particularly in primary care, should consider an assessment of sarcopenia in individuals at increased risk; suggested tools for assessing risk include the Red Flag Method, the SARC-F questionnaire, the SMI method or different prediction equations. Management of sarcopenia should primarily be patient centered and involve the combination of both resistance and endurance based activity programmes with or without dietary interventions. Development of a number of pharmacological interventions is also in progress. Conclusions: Assessment of sarcopenia in individuals with risk factors, symptoms and/or conditions exposing them to the risk of disability will become particularly important in the near future.
| langue originale | Anglais |
|---|---|
| Numéro d'article | 170 |
| Pages (de - à) | 1-10 |
| Nombre de pages | 10 |
| journal | BMC Geriatrics |
| Volume | 16 |
| Numéro de publication | 1 |
| Les DOIs | |
| Etat de la publication | Publié - 2016 |
| Modification externe | Oui |
Financement
Charlotte Beaudart: none; Eugene McCloskey has been involved with the development of the FRAX tool and with its continual update; has played a consultant/advisory role, and/or speaker and/or research funding for ActiveSignal, Amgen, ARUK, AstraZeneca, Consilient Healthcare, GSK, Hologic, i3 Innovus, Internis, IOF, Lilly, Medtronic, Merck, MRC, Novartis, Pfizer, Roche, Sanofi-Aventis, Servier, Synexus,Tethys, UCB, Unilever, and Warner Chilcott. Bruce H. Mitlak is an employee and has stock ownership in Eli Lilly and Company; Olivier Bruyère has received grant support from IBSA, Merck Sharp and Dohme, Nutraveris, Novartis, Pfizer, Rottapharm, Servier, and Theramex; lecture fees from IBSA, Rottapharm, Servier, and SMB; Matteo Cesari has received a research grant from Pfizer. Moreover, he has received honoraria for presentation at scientific meetings from Nestlé and Pfizer; Yves Rolland has received consulting and/or grant recipient from Amgen, Eli Lilly, Novartis and Lactalis; René Rizzoli has received consulting and lecture fees from Merck Sharp and Dohme, Eli Lilly, Amgen, Novartis, Servier, Nycomed, Nestlé and Danone; Islène Araujo de Carvalho: none; Jotheeswaran Amuthavalli Thiyagarajanm: none; Ivan Bautmans: none; Marie-Claude Bertière : none; Maria Luisa Brandi has received consulting and/or grant recipient from Amgen, Eli Lilly, MSD, Novartis, NPS, Roche, and Servier; Nasser Al-Daghri: none; Nansa Burlet: none; Etienne Cavalier is a consultant for DiaSorin and IDS and has received lecture fees from IDS, DiaSorin, Roche, Abbott, Pfizer and Amgen; Francesca Cerreta: none; Antonio Cherubini is a partner of the SPRINTT Consortium, which is partly funded by the European Federation of Pharmaceutical Industries and Associations (EFPIA); Roger A. Fielding has had remuneration, has played a consultant/advisory role, and has stock ownership of or funding from Eli Lilly, Dairy Management, Abbott, Pronutria, Segterra, Ammonett, Bristol Myers Squibb, Cytokinetics, Regeneron, Pfizer, Astellas, and Nestec; Evelien Gielen: none; Francesco Landi is a partner of the SPRINTT Consortium, which is partly funded by the European Federation of Pharmaceutical Industries and Associations (EFPIA); Jean Petermans is the Treasurer of the EUGMS; Jean-Yves Reginster has received consulting fees or paid advisory boards for Servier, Novartis, Negma, Lilly, Wyeth, Amgen, GlaxoSmithKline, Roche, Merckle, NycomedTakeda, NPS, IBSA-Genevrier, Theramex, UCB, Asahi Kasei, Endocyte; lecture fees from Merck Sharp and Dohme, Lilly, Rottapharm, IBSA, Genevrier, Novartis, Servier, Roche, GlaxoSmithKline, Merckle, Teijin, Teva, Analis, Theramex, Nycomed, NovoNordisk, Ebewee Pharma, Zodiac, Danone, Will Pharma, Amgen.; Grant support from Bristol Myers Squibb, Merck Sharp & Dohme, Rottapharm, Teva, Roche, Amgen, Lilly, Novartis, GlaxoSmithKline, Servier, Pfizer, Theramex, Danone, Organon, Therabel, Boehringer, Chiltern, Galapagos; Marjolein Visser: none; John A. Kanis has worked with and received funding from many companies and non-governmental organizations dealing with skeletal metabolism including research funding from the Health Technology Assessment NHS R&D HTA Programme of the UK; he has been involved with the development of the FRAX tool and with its continual update; Cyrus Cooper has received honoraria and consulting fees from Amgen, Glaxo SmithKline, ABBH, Merck Sharpe and Dohme, Eli Lilly, Pfizer, Novartis, Servier, Medtronic and Roche.