Safety of long-term treatment of HAM/TSP patients with valproic acid

S. Olindo, G. Belrose, N. Gillet, S. Rodriguez, Mathieu Boxus, O. Verlaeten, B. Asquith, C. R. M. Bangham, A. Signaté, D. Smadja, A. Lezin, R. Césaire, L. Willems

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

Résumé

[en] HTLV-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a neurodegenerative disease of the central nervous system induced by Human T lymphotropic virus type 1 (HTLV-1). As a potential therapeutic approach, we previously suggested reducing the proviral load (PVL) by modulating lysine deacetylase activity using valproic acid (VPA) and exposing virus-positive cells to the host immune response. We conducted a single-center, two-year open-label trial, with 19 HAM/TSP volunteers treated with oral VPA. PVL, CD38/HLA-DR expression and CD8+ lysis efficiency were not significantly affected by VPA. Mean scores of HAM/TSP disability did not differ between baseline and final visit. Walking Time Test (WTT) increased significantly (>20 in 3 patients and was in keeping with minor VPA side effects (drowsiness and tremor). WTT improved rapidly after VPA discontinuation. We conclude that long term treatment with VPA is safe in HAM/TSP.
langue originaleAnglais
Pages (de - à)6306-6309
Nombre de pages4
journalBlood
Volume118
Numéro de publication24
Les DOIs
Etat de la publicationPublié - 2011
Modification externeOui

Empreinte digitale

Examiner les sujets de recherche de « Safety of long-term treatment of HAM/TSP patients with valproic acid ». Ensemble, ils forment une empreinte digitale unique.

Contient cette citation