Role of the transcription activator virF and the histone-like protein YmoA in the thermoregulation of virulence functions in yersiniae

    Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

    Résumé

    The chromosome of Y. enterocolitica encodes a heat-stable enterotoxin, Yst, being related to STI. The capacity to produce Yst generally disappears during storage of the strains. In these strains, the yst gene is intact but remains silent. The pYV plasmid encodes the eleven secreted antihost proteins called Yops as well as the outer membrane protein YadA. The Yops are secreted by a novel, pYV-encoded secretion mechanism. This mechanism which does not involve the removal of an N-terminal signal sequence, is encoded by the pYV virA and virC loci. The virC locus contains 13 genes called yscA-M. The virA locus encodes the LcrD membrane protein. The yop, yadA and ysc genes form the yop regulon controlled by transcriptional activator VirF. Transcription of the yop, yadA, ysc and virF genes is controlled by temperature. A chromosome-encoded histone-like protein, called YmoA, is involved in the thermoregulation of the yop regulon, which suggests that this thermoregulation could result from temperature-induced changes in DNA topology. The phenotype of ymoA mutants resembles that of osmZ or drdX mutants of E. coli but YmoA is not the Yersinia homologue of the E. coli histone H1. The YmoA histone is also involved in the silencing of the yst gene.
    langue originaleAnglais
    Pages (de - à)149-64
    Nombre de pages16
    journalZentralblatt für Bakteriologie : international journal of medical microbiology
    Volume278
    Numéro de publication2-3
    Etat de la publicationPublié - 1993

    Empreinte digitale

    Examiner les sujets de recherche de « Role of the transcription activator virF and the histone-like protein YmoA in the thermoregulation of virulence functions in yersiniae ». Ensemble, ils forment une empreinte digitale unique.

    Contient cette citation