Retrovirally mediated overexpression of peroxiredoxin VI increases the survival of WI-38 human diploid fibroblasts exposed to cytotoxic doses of tert-butylhydroperoxide and UVB

Jean François Dierick, Frédéric Wenders, Florence Debacq-Chainiaux, José Remacle, Aron B. Fisher, Olivier Toussaint

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

Résumé

In this work, stable overexpression of peroxiredoxin VI was generated in WI-38 human diploid fibroblasts using a retrovirus-mediated transfection system. Estimation of cell survival showed that peroxiredoxin VI provides a significant protection against tert-butylhydroperoxide- or UVB-caused cytotoxicity. No protection was found against ethanol- or H2O2-caused cytotoxicity. These effects are correlated with the known functions of Prx VI.

langue originaleAnglais
Pages (de - à)125-131
Nombre de pages7
journalBiogerontology
Volume4
Numéro de publication3
Les DOIs
Etat de la publicationPublié - 18 juil. 2003

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