Activités par an
Résumé
Tumor-associated macrophages (TAMs) play a central role in tumor progression, metastasis, and recurrence after treatment. Macrophage plasticity and diversity allow their classification along a M1-M2 polarization axis. Tumor-associated macrophages usually display a M2-like phenotype, associated with pro-tumoral features whereas M1 macrophages exert antitumor functions. Targeting the reprogramming of TAMs toward M1-like macrophages would thus be an efficient way to promote tumor regression. This can be achieved through therapies including chemotherapy, immunotherapy, and radiotherapy (RT). In this review, we first describe how chemo- and immunotherapies can target TAMs and, second, we detail how RT modifies macrophage phenotype and present the molecular pathways that may be involved. The identification of irradiation dose inducing macrophage reprogramming and of the underlying mechanisms could lead to the design of novel therapeutic strategies and improve synergy in combined treatments.
langue originale | Anglais |
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Numéro d'article | 828 |
Pages (de - à) | 828 |
Nombre de pages | 19 |
journal | Frontiers in Immunology |
Volume | 8 |
Numéro de publication | JUL |
Les DOIs | |
Etat de la publication | Publié - 2017 |
Empreinte digitale
Examiner les sujets de recherche de « Reprogramming of tumor-associated macrophages with anticancer therapies: Radiotherapy versus chemo- and immunotherapies ». Ensemble, ils forment une empreinte digitale unique.Équipement
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Synthèse, Irradiation et Analyse de Matériaux (SIAM) (2016 - ...)
Pierre Louette (!!Manager), Julien Colaux (!!Manager), Alexandre Felten (!!Manager), Tijani Tabarrant (!!Operator), Frederic COME (!!Operator) & Paul-Louis Debarsy (!!Manager)
Plateforme technologique Synthese, irradiation et analyse des materiauxEquipement/installations: Plateforme technolgique
Activités
- 1 Participation à une conférence, un congrès
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63rd annual Congress of the Radiation Research Society
Stéphane Lucas (Poster)
15 oct. 2017 → 18 oct. 2017Activité: Participation ou organisation d'un événement › Participation à une conférence, un congrès
Thèses de l'étudiant
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Unravelling the effects of proton irradiation on macrophages in cancer
Auteur: Genard, G., 30 mai 2018Superviseur: Michiels, C. (Promoteur), Heuskin, A. (Président), Lucas, S. (Jury), Poumay, Y. (Jury), Feron, O. (Jury) & Huber, P. E. (Personne externe) (Jury)
Student thesis: Doc types › Docteur en Sciences
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