Relation entre la stase veineuse et l'apparition de la douleur.

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs


Venous stasis is a situation encountered commonly in varicose disorders. The potential implications of this decrease in oxygen levels in terms of the status of the cells of the vein were assessed. When endothelial cells are subjected to hypoxia, there is stimulation of the cells which shows itself as increased synthesis of prostaglandins and of PAF (Platelet Activating Factor). The synthesis of these typical mediators of inflammation results from activation by the calcium of phospholipase A2 which releases the arachidonic acid of phospholipids and this increase in intracellular calcium results itself from a fall in efficacy of calcium pumps due to the fall in ATP caused by hypoxia. Thus the fall in oxygen leads to the production of mediators of inflammation which activate leucocytes and result in local micro-inflammation which can be very rapidly eliminated if the circulation is restored but which can also cause irreversible damage to the vein by changes in venous tissue due to activated leucocytes which release proteases and free radicals after having penetrated the intima of the vein. These processes offer an explanation for the histological changes seen in varicose veins and the onset of localised pain during the development of such disease.

Titre traduit de la contributionThe relation between venous stasis and the occurrence of pain
langue originaleFrançais
Pages (de - à)33-37
Nombre de pages5
Numéro de publication1
Etat de la publicationPublié - 1992

Empreinte digitale

Examiner les sujets de recherche de « Relation entre la stase veineuse et l'apparition de la douleur. ». Ensemble, ils forment une empreinte digitale unique.

Contient cette citation