Résumé
Cyclooxygenases and lipoxygenase are key enzymes in the arachidonic acid metabolism. Dual inhibitors are drugs able to block both the COX and the 5-LOX metabolic pathways. Compared to COX or LOX pathways single inhibitors, dual inhibitors present at least two major advantages. First, dual inhibitors, by acting on the two major arachidonic acid metabolic pathways, possess a wide range of anti-inflammatory activities. Secondly, dual inhibitors appear to be almost exempt from gastric toxicity, which is the most troublesome side effect of non-selective COX inhibitors.
langue originale | Anglais |
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Pages (de - à) | 633-8 |
Nombre de pages | 6 |
journal | Mini-reviews in medicinal chemistry |
Volume | 4 |
Numéro de publication | 6 |
Etat de la publication | Publié - août 2004 |