Real-world variability in dabigatran levels in patients with atrial fibrillation: comment

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Résumé

We read with interest the recent prospective observational study by Chan et al.[1] The authors aimed to investigate the inter- and intra-patient variability in dabigatran plasma levels with the 110 and 150 mg bid dose regimens in 100 patients suffering from atrial fibrillation (AF). They also assessed the effect of physicians' dose selection on plasma levels in the two different subgroups and explored whether a single trough measurement would identify patients with extreme plasma levels on subsequent visits, i.e. at 2-, 4- and 6-months [1]. They support the practice of selecting dabigatran dose based upon clinical characteristics because it results in similar levels of drug exposure in patients given the 110 or the 150 mg bid dose regimen. However, they do not support the concept that a single plasma level measurement with the Hemoclot Thrombin Inhibitor(®) (Hyphen BioMed) can be used to identify patients with consistently high or low plasma levels. This article is protected by copyright. All rights reserved.

langue originaleAnglais
Pages (de - à)1166-1168
Nombre de pages3
journalJournal of thrombosis and haemostasis : JTH
Volume13
Numéro de publication6
Les DOIs
Etat de la publicationPublié - 1 juin 2015

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    Evaluation of thrombotic and/or bleeding risks associated with anticoagulotherapy.

    Author: Douxfils, J., 24 oct. 2015

    Superviseur: Dogne, J. (Promoteur), Mullier, F. (Promoteur), Masereel, B. (Président), Chatelain, B. (Jury), Chatelain, C. (Personne externe) (Jury), Verhamme, P. (Personne externe) (Jury), TEN CATE, H. (Personne externe) (Jury) & Ageno, W. (Personne externe) (Jury)

    Thèse de l'étudiant: Doc typesDocteur en Sciences Biomédicales et Pharmaceutiques

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