Résumé
Cell therapy is an emerging and promising regenerative approach by cell replacement for the treatment of diseases or injuries. Hydrogels, featuring high biocompatibility, tunable physicochemical properties, controllable structures, and multiple functionalization possibilities, have been developed as most-frequently-used cell reservoirs. Aiming at treating diseases or injuries with high efficiency, a series of porous and responsive hydrogels have been fabricated for the encapsulation of therapeutic cells. These cell-laden hydrogels have been applied in a broad range of pre-clinical researches of which results have demonstrated hopeful prospects in cell therapy. In this review, we highlight the recent progress of porous and responsive hydrogels used for cell encapsulation towards cell therapy. The hydrogels used for cell therapy are firstly classified. The porosity fabrication strategies of hydrogels are summarized and discussed. The responsive functionalities of hydrogels are surveyed, focusing on temperature-sensitivity, photo-sensitivity, pH-responsivity and biomolecule-sensitivity. Moreover, preclinical researches of hydrogels towards cell therapy, including the treatment of several diseases, such as diabetes mellitus, cancer, neuro disorders, cardiac diseases and bone injuries are discussed.
langue originale | Anglais |
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Pages (de - à) | 135-157 |
Nombre de pages | 23 |
journal | Current Opinion in Colloid and Interface Science |
Volume | 38 |
Les DOIs | |
Etat de la publication | Publié - 1 nov. 2018 |
Financement
This work was supported by the National Key Research and Development Program of China ( 2016YFA0102200 ), Chinese Ministry of Education in a frame work of the Changjiang Scholar Innovation Research Team Program ( IRT_15R52 ), “ Algae Factory ” ( 1610187 ) European H2020 program financed by FEDER and Wallonia Region of Belgium .
Bailleurs de fonds | Numéro du bailleur de fonds |
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Changjiang Scholar Innovation Research Team Program | 1610187 |
Wallonia Region of Belgium | |
Ministry of Education of the People's Republic of China | |
Federación Española de Enfermedades Raras | |
Changjiang Scholar Program of Chinese Ministry of Education | IRT_15R52 |
European Regional Development Fund | |
National Key Research and Development Program of China | 2016YFA0102200 |
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Physico-chimie et caractérisation (PC2)
Wouters, J. (!!Manager), Aprile, C. (!!Manager) & Fusaro, L. (!!Manager)
Plateforme technologique Caracterisation physico-chimiquesEquipement/installations: Plateforme technolgique