Porous and responsive hydrogels for cell therapy

Li Wang, Myriam Neumann, Tianlong Fu, Weida Li, Xin Cheng, Bao Lian Su

Résultats de recherche: Contribution à un journal/une revueArticle de revue

Résumé

Cell therapy is an emerging and promising regenerative approach by cell replacement for the treatment of diseases or injuries. Hydrogels, featuring high biocompatibility, tunable physicochemical properties, controllable structures, and multiple functionalization possibilities, have been developed as most-frequently-used cell reservoirs. Aiming at treating diseases or injuries with high efficiency, a series of porous and responsive hydrogels have been fabricated for the encapsulation of therapeutic cells. These cell-laden hydrogels have been applied in a broad range of pre-clinical researches of which results have demonstrated hopeful prospects in cell therapy. In this review, we highlight the recent progress of porous and responsive hydrogels used for cell encapsulation towards cell therapy. The hydrogels used for cell therapy are firstly classified. The porosity fabrication strategies of hydrogels are summarized and discussed. The responsive functionalities of hydrogels are surveyed, focusing on temperature-sensitivity, photo-sensitivity, pH-responsivity and biomolecule-sensitivity. Moreover, preclinical researches of hydrogels towards cell therapy, including the treatment of several diseases, such as diabetes mellitus, cancer, neuro disorders, cardiac diseases and bone injuries are discussed.

langue originaleAnglais
Pages (de - à)135-157
Nombre de pages23
journalCurrent Opinion in Colloid and Interface Science
Volume38
Les DOIs
étatPublié - 1 nov. 2018

Empreinte digitale

Hydrogels
therapy
cells
Encapsulation
Photosensitivity
diabetes mellitus
Biomolecules
Medical problems
Biocompatibility
photosensitivity
sensitivity
biocompatibility
Bone
Porosity
bones
emerging
Fabrication
cancer
disorders
porosity

Citer ceci

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abstract = "Cell therapy is an emerging and promising regenerative approach by cell replacement for the treatment of diseases or injuries. Hydrogels, featuring high biocompatibility, tunable physicochemical properties, controllable structures, and multiple functionalization possibilities, have been developed as most-frequently-used cell reservoirs. Aiming at treating diseases or injuries with high efficiency, a series of porous and responsive hydrogels have been fabricated for the encapsulation of therapeutic cells. These cell-laden hydrogels have been applied in a broad range of pre-clinical researches of which results have demonstrated hopeful prospects in cell therapy. In this review, we highlight the recent progress of porous and responsive hydrogels used for cell encapsulation towards cell therapy. The hydrogels used for cell therapy are firstly classified. The porosity fabrication strategies of hydrogels are summarized and discussed. The responsive functionalities of hydrogels are surveyed, focusing on temperature-sensitivity, photo-sensitivity, pH-responsivity and biomolecule-sensitivity. Moreover, preclinical researches of hydrogels towards cell therapy, including the treatment of several diseases, such as diabetes mellitus, cancer, neuro disorders, cardiac diseases and bone injuries are discussed.",
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Porous and responsive hydrogels for cell therapy. / Wang, Li; Neumann, Myriam; Fu, Tianlong; Li, Weida; Cheng, Xin; Su, Bao Lian.

Dans: Current Opinion in Colloid and Interface Science, Vol 38, 01.11.2018, p. 135-157.

Résultats de recherche: Contribution à un journal/une revueArticle de revue

TY - JOUR

T1 - Porous and responsive hydrogels for cell therapy

AU - Wang, Li

AU - Neumann, Myriam

AU - Fu, Tianlong

AU - Li, Weida

AU - Cheng, Xin

AU - Su, Bao Lian

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Cell therapy is an emerging and promising regenerative approach by cell replacement for the treatment of diseases or injuries. Hydrogels, featuring high biocompatibility, tunable physicochemical properties, controllable structures, and multiple functionalization possibilities, have been developed as most-frequently-used cell reservoirs. Aiming at treating diseases or injuries with high efficiency, a series of porous and responsive hydrogels have been fabricated for the encapsulation of therapeutic cells. These cell-laden hydrogels have been applied in a broad range of pre-clinical researches of which results have demonstrated hopeful prospects in cell therapy. In this review, we highlight the recent progress of porous and responsive hydrogels used for cell encapsulation towards cell therapy. The hydrogels used for cell therapy are firstly classified. The porosity fabrication strategies of hydrogels are summarized and discussed. The responsive functionalities of hydrogels are surveyed, focusing on temperature-sensitivity, photo-sensitivity, pH-responsivity and biomolecule-sensitivity. Moreover, preclinical researches of hydrogels towards cell therapy, including the treatment of several diseases, such as diabetes mellitus, cancer, neuro disorders, cardiac diseases and bone injuries are discussed.

AB - Cell therapy is an emerging and promising regenerative approach by cell replacement for the treatment of diseases or injuries. Hydrogels, featuring high biocompatibility, tunable physicochemical properties, controllable structures, and multiple functionalization possibilities, have been developed as most-frequently-used cell reservoirs. Aiming at treating diseases or injuries with high efficiency, a series of porous and responsive hydrogels have been fabricated for the encapsulation of therapeutic cells. These cell-laden hydrogels have been applied in a broad range of pre-clinical researches of which results have demonstrated hopeful prospects in cell therapy. In this review, we highlight the recent progress of porous and responsive hydrogels used for cell encapsulation towards cell therapy. The hydrogels used for cell therapy are firstly classified. The porosity fabrication strategies of hydrogels are summarized and discussed. The responsive functionalities of hydrogels are surveyed, focusing on temperature-sensitivity, photo-sensitivity, pH-responsivity and biomolecule-sensitivity. Moreover, preclinical researches of hydrogels towards cell therapy, including the treatment of several diseases, such as diabetes mellitus, cancer, neuro disorders, cardiac diseases and bone injuries are discussed.

KW - Cell encapsulation

KW - Cell therapy

KW - Hydrogels

KW - Porosity

KW - Stimuli-responsivity

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