TY - JOUR
T1 - Polymorphism of N-stearoylethanolamine
T2 - Differential scanning calorimetric, vibrational spectroscopic (FTIR), and crystallographic studies
AU - Wouters, J.
AU - Vandevoorde, S.
AU - Culot, C.
AU - Docquir, F.
AU - Lambert, D. M.
PY - 2002/10/1
Y1 - 2002/10/1
N2 - Based on a series of physicochemical properties (differential scanning calorimetry, powder X-ray crystallographic studies and Fourier-transform infra red spectroscopic analysis) determined for N-stearoylethanolamine (NSEA) (C18:0) at different temperatures, evidence has been given that this compound can exist in (at least) three polymorphic forms. Powder X-ray crystallography clearly demonstrates the presence of three distinct molecular packings at distinct temperatures while spectral changes in the vibrational spectra reveal that the geometry of the CH2-CO functional group of the molecule is affected during the polymorphic transitions. Rationalization of the thermal physicochemical behavior of NSEA in terms of molecular packing is also proposed. It supposes rearrangement of the hydrocarbon chains upon heating of the molecule.
AB - Based on a series of physicochemical properties (differential scanning calorimetry, powder X-ray crystallographic studies and Fourier-transform infra red spectroscopic analysis) determined for N-stearoylethanolamine (NSEA) (C18:0) at different temperatures, evidence has been given that this compound can exist in (at least) three polymorphic forms. Powder X-ray crystallography clearly demonstrates the presence of three distinct molecular packings at distinct temperatures while spectral changes in the vibrational spectra reveal that the geometry of the CH2-CO functional group of the molecule is affected during the polymorphic transitions. Rationalization of the thermal physicochemical behavior of NSEA in terms of molecular packing is also proposed. It supposes rearrangement of the hydrocarbon chains upon heating of the molecule.
KW - Differential scanning calorimetry
KW - N-acylethanolamines
KW - Polymorphism
KW - Powder diffraction
KW - Vibrational spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=0036775125&partnerID=8YFLogxK
U2 - 10.1016/S0009-3084(02)00031-2
DO - 10.1016/S0009-3084(02)00031-2
M3 - Article
C2 - 12270669
AN - SCOPUS:0036775125
SN - 0009-3084
VL - 119
SP - 13
EP - 21
JO - Chemistry and Physics of Lipids
JF - Chemistry and Physics of Lipids
IS - 1-2
ER -