Persistent heparin-induced thrombocytopenia: Danaparoid cross-reactivity or delayed-onset heparin-induced thrombocytopenia? A case report

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Résumé

Clinical suspicion of immune heparin-induced thrombocytopenia (HIT) requires cessation of heparin and initiation of an alternative anticoagulant. The platelet count will subsequently recover. This case report describes the clinical course of a patient after a cardiovascular surgery. HIT was clinically and biologically confirmed. Unexpectedly, the platelet count did not recover despite the arrest of heparin. Danaparoid was initiated, and thrombocytopenia persisted. Danaparoid cross-reactivity was suspected, and laboratory assay was performed. Results were misinterpreted because no comparative buffer control was performed to ensure that the platelet aggregation was caused by danaparoid. Moreover, plasma/serum must be diluted to demonstrate this effect. Danaparoid cross-reactivity was incorrectly concluded, and the patient was switched to bivalirudin. The severe thrombocytopenia persisted. Plasmapheresis was started, and platelet count finally increased. The clinical course suggested a delayed-onset HIT. This case report illustrates the need for appropriate testing to differentiate drug cross-reactivity from delayed-onset HIT.

langue originaleAnglais
Pages (de - à)193-197
Nombre de pages5
journalBlood Coagulation and Fibrinolysis
Volume28
Numéro de publication2
Les DOIs
Etat de la publicationPublié - 1 mars 2017

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  • Thèses de l'étudiant

    Analytical and clinical validation of sensitive assays for the diagnosis of immune heparin-induced thrombocytopenia

    Author: Minet, V., 2017

    Superviseur: Dogne, J. (Promoteur), Mullier, F. (Personne externe) (Copromoteur), Laloy, J. (Jury), Lucas, S. (Jury), Masereel, B. (Jury), Chatelain, M. (Personne externe) (Jury), Hoylaerts, M. F. (Personne externe) (Jury) & Tardy, B. (Personne externe) (Jury)

    Thèse de l'étudiant: Doc typesDocteur en Sciences Biomédicales et Pharmaceutiques

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