Partial alkyne reduction in flow: Adaptation of the lindlar protocol prompted by a flow synthesis of combretastatin A-4

Résultats de recherche: Contribution à un événement scientifique (non publié)Poster

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Résumé

Combretastatin A-4 (1) is a natural product isolated from the South African bushwillow tree Combretum caffrum and endowed with a powerful inhibitory activity on microtubule formation as well as a related antiangiogenic activity.1-3 As such, 1 has a strong potential in the anticancer therapy. A lot of effort has been done on the development of new derivatives of this compound, in order to improve the properties such as solubility and stability and to understand the structure-activity relationships around this series.4-7 Our group has recently turned its attention to developing a synthetic procedure for combretastatin A-4 performed entirely in flow, which should enable continuous production of this useful compound and its derivatives in significant quantities. The full results of this work will be presented in due course.

A crucial step in this synthetic strategy is a selective semi-reduction of the triple bond of an alkyne precursor to the Z-double bond present in the final product. The Lindlar-type hydrogenation in flow has been described only scarcely and for products more stable than Z-stilbenes.8 We therefore set out to explore the applicability of this technique within our synthetic procedure and also decided to expand it to a wider range of structurally various alkynes. The experimental conditions have been varied according to the general scheme below and the - rather promising - results are shown in the poster.
langue originaleAnglais
étatPublié - 16 oct. 2013
EvénementFROST4 - 4th Conference on Frontiers in Organic Synthesis Technology - Budapest, Hongrie
Durée: 16 oct. 201318 oct. 2013

Une conférence

Une conférenceFROST4 - 4th Conference on Frontiers in Organic Synthesis Technology
PaysHongrie
La villeBudapest
période16/10/1318/10/13

Empreinte digitale

Alkynes
Derivatives
Biological Products
Hydrogenation
Solubility
fosbretabulin

Citer ceci

De Backer, L., Dolušić, E., Collin, S., & Lanners, S. (2013). Partial alkyne reduction in flow: Adaptation of the lindlar protocol prompted by a flow synthesis of combretastatin A-4. Poster présenté � FROST4 - 4th Conference on Frontiers in Organic Synthesis Technology, Budapest, Hongrie.
De Backer, Laurent ; Dolušić, Eduard ; Collin, Stéphane ; Lanners, Steve. / Partial alkyne reduction in flow : Adaptation of the lindlar protocol prompted by a flow synthesis of combretastatin A-4. Poster présenté � FROST4 - 4th Conference on Frontiers in Organic Synthesis Technology, Budapest, Hongrie.
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title = "Partial alkyne reduction in flow: Adaptation of the lindlar protocol prompted by a flow synthesis of combretastatin A-4",
abstract = "Combretastatin A-4 (1) is a natural product isolated from the South African bushwillow tree Combretum caffrum and endowed with a powerful inhibitory activity on microtubule formation as well as a related antiangiogenic activity.1-3 As such, 1 has a strong potential in the anticancer therapy. A lot of effort has been done on the development of new derivatives of this compound, in order to improve the properties such as solubility and stability and to understand the structure-activity relationships around this series.4-7 Our group has recently turned its attention to developing a synthetic procedure for combretastatin A-4 performed entirely in flow, which should enable continuous production of this useful compound and its derivatives in significant quantities. The full results of this work will be presented in due course.A crucial step in this synthetic strategy is a selective semi-reduction of the triple bond of an alkyne precursor to the Z-double bond present in the final product. The Lindlar-type hydrogenation in flow has been described only scarcely and for products more stable than Z-stilbenes.8 We therefore set out to explore the applicability of this technique within our synthetic procedure and also decided to expand it to a wider range of structurally various alkynes. The experimental conditions have been varied according to the general scheme below and the - rather promising - results are shown in the poster.",
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De Backer, L, Dolušić, E, Collin, S & Lanners, S 2013, 'Partial alkyne reduction in flow: Adaptation of the lindlar protocol prompted by a flow synthesis of combretastatin A-4', FROST4 - 4th Conference on Frontiers in Organic Synthesis Technology, Budapest, Hongrie, 16/10/13 - 18/10/13.

Partial alkyne reduction in flow : Adaptation of the lindlar protocol prompted by a flow synthesis of combretastatin A-4. / De Backer, Laurent; Dolušić, Eduard; Collin, Stéphane; Lanners, Steve.

2013. Poster présenté � FROST4 - 4th Conference on Frontiers in Organic Synthesis Technology, Budapest, Hongrie.

Résultats de recherche: Contribution à un événement scientifique (non publié)Poster

TY - CONF

T1 - Partial alkyne reduction in flow

T2 - Adaptation of the lindlar protocol prompted by a flow synthesis of combretastatin A-4

AU - De Backer, Laurent

AU - Dolušić, Eduard

AU - Collin, Stéphane

AU - Lanners, Steve

PY - 2013/10/16

Y1 - 2013/10/16

N2 - Combretastatin A-4 (1) is a natural product isolated from the South African bushwillow tree Combretum caffrum and endowed with a powerful inhibitory activity on microtubule formation as well as a related antiangiogenic activity.1-3 As such, 1 has a strong potential in the anticancer therapy. A lot of effort has been done on the development of new derivatives of this compound, in order to improve the properties such as solubility and stability and to understand the structure-activity relationships around this series.4-7 Our group has recently turned its attention to developing a synthetic procedure for combretastatin A-4 performed entirely in flow, which should enable continuous production of this useful compound and its derivatives in significant quantities. The full results of this work will be presented in due course.A crucial step in this synthetic strategy is a selective semi-reduction of the triple bond of an alkyne precursor to the Z-double bond present in the final product. The Lindlar-type hydrogenation in flow has been described only scarcely and for products more stable than Z-stilbenes.8 We therefore set out to explore the applicability of this technique within our synthetic procedure and also decided to expand it to a wider range of structurally various alkynes. The experimental conditions have been varied according to the general scheme below and the - rather promising - results are shown in the poster.

AB - Combretastatin A-4 (1) is a natural product isolated from the South African bushwillow tree Combretum caffrum and endowed with a powerful inhibitory activity on microtubule formation as well as a related antiangiogenic activity.1-3 As such, 1 has a strong potential in the anticancer therapy. A lot of effort has been done on the development of new derivatives of this compound, in order to improve the properties such as solubility and stability and to understand the structure-activity relationships around this series.4-7 Our group has recently turned its attention to developing a synthetic procedure for combretastatin A-4 performed entirely in flow, which should enable continuous production of this useful compound and its derivatives in significant quantities. The full results of this work will be presented in due course.A crucial step in this synthetic strategy is a selective semi-reduction of the triple bond of an alkyne precursor to the Z-double bond present in the final product. The Lindlar-type hydrogenation in flow has been described only scarcely and for products more stable than Z-stilbenes.8 We therefore set out to explore the applicability of this technique within our synthetic procedure and also decided to expand it to a wider range of structurally various alkynes. The experimental conditions have been varied according to the general scheme below and the - rather promising - results are shown in the poster.

KW - Lindlar reduction, combretastatin A-4

M3 - Poster

ER -

De Backer L, Dolušić E, Collin S, Lanners S. Partial alkyne reduction in flow: Adaptation of the lindlar protocol prompted by a flow synthesis of combretastatin A-4. 2013. Poster présenté � FROST4 - 4th Conference on Frontiers in Organic Synthesis Technology, Budapest, Hongrie.