Palladium-nanoparticle-catalyzed 1,7-palladium migration involving C-H activation, followed by intramolecular lamination: Regioselective synthesis of N 1-arylbenzotriazoles and an evaluation of their inhibitory activity toward indoleamine 2,3-dioxygenase

Koji Takagi, Mohammad Al-Amin, Naoyuki Hoshiya, Johan Wouters, Hiroshi Sugimoto, Yoshitsugu Shiro, Hayato Fukuda, Satoshi Shuto, Mitsuhiro Arisawa

Résultats de recherche: Contribution à un journal/une revueArticle

Résumé

A sulfur-modified gold-supported palladium material (SAPd) has been developed bearing palladium nanoparticles on its surface. Herein, we report for the first time the use of SAPd to affect a Pd-nanoparticle-catalyzed 1,7-Pd migration reaction for the synthesis of benzotriazoles via C-H bond activation. The resulting benzotriazoles were evaluated in terms of their inhibitory activity toward indoleamine 2,3-dioxygenase.

langue originaleAnglais
Pages (de - à)6366-6371
Nombre de pages6
journalJournal of Organic Chemistry
Volume79
Numéro de publication13
Les DOIs
étatPublié - 3 juil. 2014

Empreinte digitale

Indoleamine-Pyrrole 2,3,-Dioxygenase
Palladium
Nanoparticles
Bearings (structural)
Chemical activation
Sulfur
Gold
benzotriazole

Citer ceci

Takagi, Koji ; Al-Amin, Mohammad ; Hoshiya, Naoyuki ; Wouters, Johan ; Sugimoto, Hiroshi ; Shiro, Yoshitsugu ; Fukuda, Hayato ; Shuto, Satoshi ; Arisawa, Mitsuhiro. / Palladium-nanoparticle-catalyzed 1,7-palladium migration involving C-H activation, followed by intramolecular lamination: Regioselective synthesis of N 1-arylbenzotriazoles and an evaluation of their inhibitory activity toward indoleamine 2,3-dioxygenase. Dans: Journal of Organic Chemistry. 2014 ; Vol 79, Numéro 13. p. 6366-6371.
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abstract = "A sulfur-modified gold-supported palladium material (SAPd) has been developed bearing palladium nanoparticles on its surface. Herein, we report for the first time the use of SAPd to affect a Pd-nanoparticle-catalyzed 1,7-Pd migration reaction for the synthesis of benzotriazoles via C-H bond activation. The resulting benzotriazoles were evaluated in terms of their inhibitory activity toward indoleamine 2,3-dioxygenase.",
author = "Koji Takagi and Mohammad Al-Amin and Naoyuki Hoshiya and Johan Wouters and Hiroshi Sugimoto and Yoshitsugu Shiro and Hayato Fukuda and Satoshi Shuto and Mitsuhiro Arisawa",
year = "2014",
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Palladium-nanoparticle-catalyzed 1,7-palladium migration involving C-H activation, followed by intramolecular lamination: Regioselective synthesis of N 1-arylbenzotriazoles and an evaluation of their inhibitory activity toward indoleamine 2,3-dioxygenase. / Takagi, Koji; Al-Amin, Mohammad; Hoshiya, Naoyuki; Wouters, Johan; Sugimoto, Hiroshi; Shiro, Yoshitsugu; Fukuda, Hayato; Shuto, Satoshi; Arisawa, Mitsuhiro.

Dans: Journal of Organic Chemistry, Vol 79, Numéro 13, 03.07.2014, p. 6366-6371.

Résultats de recherche: Contribution à un journal/une revueArticle

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AU - Takagi, Koji

AU - Al-Amin, Mohammad

AU - Hoshiya, Naoyuki

AU - Wouters, Johan

AU - Sugimoto, Hiroshi

AU - Shiro, Yoshitsugu

AU - Fukuda, Hayato

AU - Shuto, Satoshi

AU - Arisawa, Mitsuhiro

PY - 2014/7/3

Y1 - 2014/7/3

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DO - 10.1021/jo5009838

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