p53 and ATF-2 partly mediate the overexpression of COX-2 in H2 O2-induced premature senescence of human fibroblasts

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Résumé

Cyclooxygenase-2 and release of prostaglandin E2 are up-regulated in replicative senescence of dermal and prostate fibroblasts and in H2O2-induced premature senescence of IMR-90 lung fibroblasts expressing the catalytic subunit of telomerase. Inhibition of cyclooxygenase-2 activity by specific chemical inhibitor or siRNA attenuates the H2O2-induced increase of senescence associated β-galactosidase positive cells and attenuates growth arrest. In this work, p38MAPK activation and increased DNA binding activities of ATF-2 and p53 are shown to mediate cyclooxygenase-2 overexpression in premature senescence.

langue originaleAnglais
Pages (de - à)291-298
Nombre de pages8
journalBiogerontology
Volume10
Numéro de publication3
Les DOIs
Etat de la publicationPublié - 1 janv. 2009

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